Significant suppression of rat liver aldolase B by a toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl

被引：8

作者：

Ishii, Y ^{[1
]}

Kato, H ^{[1
]}

Hatsumura, M ^{[1
]}

Ishida, T ^{[1
]}

Ariyoshi, N ^{[1
]}

Oguri, K ^{[1
]}

机构：

[1] KYUSHU UNIV 62,FAC PHARMACEUT SCI,HIGASHI KU,FUKUOKA 81282,JAPAN

来源：

TOXICOLOGY | 1997年 / 116卷 / 1-3期

关键词：

3,3',4,4',5-pentachlorobiphenyl (PCB 126); aldolase; rat liver; gluconeogenesis; inhibition; polychlorinated biphenyl (PCB); amino acid sequence (peptide mapping);

D O I：

10.1016/S0300-483X(96)03543-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl (PenCB), significantly suppresses the expression of liver aldolase B in rats, Hepatic aldolase activity in PenCB-treated rats was significantly reduced to about 50% of that in free- and pair-fed control groups. The reduced aldolase activity following PenCB-treatment was due to the marked suppression of the expression of aldolase B shown by immunoblot analysis after SDS-polyacrylamide gel electrophoresis and two-dimensional gel electrophoresis. The suppression of rat liver aldolase B could be a key biochemical lesion caused by PenCB. Copyright (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：193 / 199

页数：7

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