Conjunctival modifications induced by medical and surgical therapies in patients with glaucoma

被引：52

作者：

Mastropasqua, Leonardo ^{[1
]}

Agnifili, Luca ^{[1
]}

Mastropasqua, Rodolfo ^{[2
]}

Fasanella, Vincenzo ^{[1
]}

机构：

[1] Univ G dAnnunzio, Ophthalm Clin, Dept Med & Ageing Sci, Chieti, Italy

[2] Univ Verona, Ophthalmol Unit, Dept Neurol Neuropsychol Morphol & Movement Sci, I-37100 Verona, Italy

来源：

CURRENT OPINION IN PHARMACOLOGY | 2013年 / 13卷 / 01期

关键词：

OPEN-ANGLE GLAUCOMA; TOPICAL ANTIGLAUCOMA DRUGS; IN-VIVO ANALYSIS; BENZALKONIUM CHLORIDE; OCULAR SURFACE; INFLAMMATORY MARKERS; MITOMYCIN-C; CELLS; LATANOPROST; EXPRESSION;

D O I：

10.1016/j.coph.2012.10.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lowering intra-ocular pressure, either medically or surgically, is the proven strategy to control glaucoma, though profound changes to the ocular surface and conjunctiva are caused. Toxicity and allergy initiated by medical therapy induce modifications, which progressively worsen with the length of treatment and number of drugs. Conjunctival changes lead to symptoms of ocular surface disease, reduced quality of life, reduced therapeutic compliance and increased risk of surgical failure. Surgery modifies conjunctiva by inducing bleb formation in fistulizing techniques, and by activating secondary aqueous humour outflow pathways, such as trans-scleral routes; in both filtration and bleb-less approaches. The use of unpreserved medications, limitation of intra-operative conjunctival damage and development of bleb-less surgery are advisable.

引用

页码：56 / 64

页数：9

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