Studies on different hydrolysis procedures for drugs of abuse in hair

被引：0

作者：

Ma, C

Zhou, TH

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 1999年 / 10卷 / 03期

关键词：

drugs of abuse; hydrolysis; hair;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Different hydrolysis and extraction procedures have been studied for the determination of drugs of abuse in hair samples. The results showed that acid and enzymatic hydrolysis gave high extraction recoveries for 6-monoacetylmorphine, morphine, codeine and heroin. Enzymatic hydrolysis was more expensive. After alkaline hydrolysis, 6-monoacetylmorphine, a unique proof of heroin abuse, could not be detected and after methanolic extraction, the extract was dirty and the obtained chromatogram showed an interfering background. It is concluded that acid hydrolysis is the extraction method of choice.

引用

页码：239 / 242

页数：4

共 8 条

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