MAPLE deposition of PLGA:PEG films for controlled drug delivery: Influence of PEG molecular weight

被引：15

作者：

Paun, Irina Alexandra ^{[1
]}

Moldovan, Antoniu ^{[2
]}

Luculescu, Catalin Romeo ^{[2
]}

Staicu, Angela ^{[2
]}

Dinescu, Maria ^{[2
]}

机构：

[1] Univ Politehn Bucuresti, Fac Sci Appl, RO-060042 Bucharest, Romania

[2] Natl Inst Laser Plasma & Radiat Phys, RO-077125 Bucharest, Romania

来源：

APPLIED SURFACE SCIENCE | 2012年 / 258卷 / 23期

关键词：

MAPLE; Polymers; Drug delivery; PULSED-LASER EVAPORATION; IN-VITRO; BLOOD COMPATIBILITY; RELEASE BEHAVIOR; POLYMER; MATRIX; DEGRADATION; NANOPARTICLES; POLY(D; L-LACTIDE-CO-GLYCOLIDE); DEPENDENCE;

D O I：

10.1016/j.apsusc.2011.10.044

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Implantable devices consisting of indomethacin (INC) cores coated with poly(lactide-co-glycolide): polyethylene glycol films (i.e. PLGA: PEG films) deposited by Matrix Assisted Pulsed Laser Evaporation (MAPLE) were produced. To predict their behavior after implantation inside the body, the implants were studied in vitro, in media similar with those encountered inside the body (phosphate buffered saline (PBS) pH 7.4 and blood). The influence of the molecular weight of PEG (i.e. low (1450 Da) versus high (10 kDa) molecular weights) on the characteristics of the implants was investigated, in terms of morphology, blood compatibility and kinetics of the drug release. The use of PEG of high molecular weight resulted in larger pores on the implants surfaces, enhanced blood compatibility of the implants and higher drug delivery rates. For both molecular weights PEGs, sustained release of INC was maintained over a three weeks interval. Theoretical fitting of the drug release data with Higuchi's model indicated that the INC was released mainly by diffusion, most probably through the pores formed in PLGA: PEG films during PBS immersion. (C) 2011 Elsevier B. V. All rights reserved.

引用

页码：9302 / 9308

页数：7

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