Whole-genome sequencing of East Asian lung cancers reveals new germline pathogenic variants

被引：1384

作者：

Mukherjee, Semanti ^{[1
,2
]}

Carrot-Zhang, Jian ^{[1
,3
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

[2] Weill Cornell Med Coll, Dept Med, New York, NY USA

[3] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10065 USA

来源：

CANCER CELL | 2022年 / 40卷 / 10期

关键词：

METABOLISM;

D O I：

10.1016/j.immuni.2015.02.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this issue of Cancer Cell, Wang et al. use whole-genome sequencing of lung cancer cases and controls with East Asian ancestry to comprehensively characterize both common and rare variants that predispose to lung cancer. Their findings suggest that rare promoter variants in BRCA2 are associated with increased lung can-cer risk.

引用

页码：1081 / 1083

页数：3