Enhancement of antibiotic-activity through complexation with metal ions - Combined ITC, MAR, enzymatic and biological studies

被引：46

作者：

Mohler, Jasper S. ^{[1
]}

Kolmar, Theresa ^{[1
]}

Synnatschke, Kevin ^{[1
]}

Hergert, Marcel ^{[1
]}

Wilson, Liam A. ^{[1
]}

Ramu, Soumya ^{[2
]}

Elliott, Alysha G. ^{[2
]}

Blaskovich, Mark A. T. ^{[2
]}

Sidjabat, Hanna E. ^{[3
]}

Paterson, David L. ^{[3
]}

Schenk, Gerhard ^{[1
]}

Cooper, Matthew A. ^{[2
]}

Ziora, Zyta M. ^{[2
]}

机构：

[1] Univ Queensland, Sch Chem & Mol Biosci, St Lucia, Qld 4072, Australia

[2] Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072, Australia

[3] Univ Queensland, Royal Brisbane & Womens Hosp, UQ Ctr Clin Res, Brisbane, Qld 4029, Australia

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2017年 / 167卷

基金：

澳大利亚研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

beta-Lactam antibiotic; beta-Lactamases; Metal-antibiotic complexes; Multi-drug resistant bacteria; Synergism; BETA-LACTAMASE; ANTIBACTERIAL ACTIVITY; SILVER NANOPARTICLES; INHIBITOR; RESISTANCE; COPPER(II); MECHANISM;

D O I：

10.1016/j.jinorgbio.2016.11.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alternative solutions need to be developed to overcome the growing problem of multi-drug resistant bacteria. This study explored the possibility of creating complexes of antibiotics with metal ions, thereby increasing their activity. Analytical techniques such as isothermal titration calorimetry and nuclear magnetic resonance were used to examine the structure and interactions between Cu(II), Ag(I) or Zn(II) and beta-lactam antibiotics. The metal-beta-lactam complexes were also tested for antimicrobial activity, by micro-broth dilution and disk diffusion methods, showing a synergistic increase in the activity of the drugs, and enzymatic inhibition assays confirming inhibition of beta-lactamases responsible for resistance. The metal-antibiotic complex concept was proven to be successful with the activity of the drugs enhanced against beta-lactamase-producing bacteria. The highest synergistic effects were observed for complexes formed with Ag(I). (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：134 / 141

页数：8

共 37 条

[1] Synthesis and antibacterial activity of ceftriaxone metal complexes [J].

Anacona, JR ;

Rodriguez, A .

TRANSITION METAL CHEMISTRY, 2005, 30 (07) :897-901

[2] Synthesis and antibacterial activity of copper(II) complexes with sulphathiazole and cephalosporin ligands [J].

Anacona, Juan R. ;

Osorio, Ivor .

TRANSITION METAL CHEMISTRY, 2008, 33 (04) :517-521

[3] Design, synthesis, and in vitro and biological evaluation of potent amino acid-derived thiol inhibitors of the metallo-β-lactamase IMP-1 [J].

Arjomandi, Omid Khalili ;

Hussein, Waleed M. ;

Vella, Peter ;

Yusof, Yusralina ;

Sidjabat, Hanna E. ;

Schenk, Gerhard ;

McGeary, Ross P. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 114 :318-327

[4] Trends in infectious disease mortality in the United States during the 20th century [J].

Armstrong, GL ;

Conn, LA ;

Pinner, RW .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 281 (01) :61-66

[5] Characterization and activity of cephalosporin metal complexes [J].

Auda, S. H. ;

Mrestani, Y. ;

Fetouh, M. I. ;

Neubert, R. H. H. .

PHARMAZIE, 2008, 63 (08) :555-561

[6]

Butler M.S., 2016, J ANTIBIOT

[7] Metalloantibiotics: Synthesis and antibacterial activity of cobalt(II), copper(II), nickel(II) and zinc(II) complexes of kefzol [J].

Chohan, ZH ;

Supuran, CT ;

Scozzafava, A .

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2004, 19 (01) :79-84

[8] Fix the antibiotics pipeline [J].

Cooper, Matthew A. ;

Shlaes, David .

NATURE, 2011, 472 (7341) :32-32

[9] Metallo-β-lactamases:: Novel weaponry for antibiotic resistance in bacteria [J].

Crowder, Michael W. ;

Spencer, James ;

Vila, Alejandro J. .

ACCOUNTS OF CHEMICAL RESEARCH, 2006, 39 (10) :721-728

[10] Alternatives to antibiotics-a pipeline portfolio review [J].

Czaplewski, Lloyd ;

Bax, Richard ;

Clokie, Martha ;

Dawson, Mike ;

Fairhead, Heather ;

Fischetti, Vincent A. ;

Foster, Simon ;

Gilmore, Brendan F. ;

Hancock, Robert E. W. ;

Harper, David ;

Henderson, Ian R. ;

Hilpert, Kai ;

Jones, Brian V. ;

Kadioglu, Aras ;

Knowles, David ;

Olafsdottir, Sigridur ;

Payne, David ;

Projan, Steve ;

Shaunak, Sunil ;

Silverman, Jared ;

Thomas, Christopher M. ;

Trust, Trevor J. ;

Warn, Peter ;

Rex, John H. .

LANCET INFECTIOUS DISEASES, 2016, 16 (02) :239-251

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