Carbapenem-resistant Enterobacteriaceae in Pediatric Bloodstream Infections in Rural Southern India

被引：12

作者：

Sekar, Ramalingam ^{[1
]}

Mythreyee, Manoharan ^{[1
]}

Srivani, Seetharaman ^{[3
]}

Sivakumaran, Dharmaraj ^{[2
]}

Lallitha, Sivathanu ^{[1
]}

Saranya, Selvam ^{[1
]}

机构：

[1] Tamilnadu Dr MGR Med Univ, Govt Theni Med Coll, Dept Microbiol, Theni, India

[2] Tamilnadu Dr MGR Med Univ, Govt Theni Med Coll, Dept Pediat, Theni, India

[3] Univ Madras, Dept Microbiol, Dr ALM Post Grad Inst Basic Med Sci, Chennai, Tamil Nadu, India

来源：

INDIAN PEDIATRICS | 2017年 / 54卷 / 12期

关键词：

Antimicrobial resistance; Blood culture; Escherichia coli; Klebsiella spp;

D O I：

10.1007/s13312-017-1204-1

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objective: To measure the frequency of antimicrobial resistance in pediatric blood culture isolates of Escherichia coli and Klebsiella spp. with focus on carbapenem resistance. Methods: Over a period of three years, pediatric blood culture isolates were tested for antimicrobial susceptibility, including molecular investigations for carbapenem resistance. Results: Amikacin, carbapenems, colistin and tigecycline had an antimicrobial efficacy of >70% (n=140). 7 of the 15 randomly selected isolates were positive for carbapenemase gene; among them, five were New Delhi Metallo beta-lactamase (NDM). Conclusion: There was a high prevalence of Klebsiella spp. in pediatric bacteremia and dissemination of NDM-mediated carbapenem resistance in pediatric wards.

引用

页码：1021 / 1024

页数：4

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