The Acute-on-Chronic Liver Failure Syndrome, or When the Innate Immune System Goes Astray

被引：87

作者：

Claria, Joan ^{[1
,2
]}

Arroyo, Vicente ^{[3
]}

Moreau, Richard ^{[4
]}

机构：

[1] Hosp Clin Barcelona, Serv Bioquim & Genet Mol, Inst Invest Biomed August Pi & Sunyer, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Barcelona 08036, Spain

[2] Univ Barcelona, Dept Biomed Sci, E-08036 Barcelona, Spain

[3] European Fdn Study Chron Liver Failure, Barcelona 08021, Spain

[4] Univ Paris Diderot, Ctr Rech Inflammat, INSERM, F-75018 Paris, France

来源：

JOURNAL OF IMMUNOLOGY | 2016年 / 197卷 / 10期

关键词：

INTERLEUKIN-1 RECEPTOR ANTAGONIST; TNF-ALPHA PRODUCTION; EMERGENCY HEMATOPOIESIS; MOLECULAR-MECHANISMS; STERILE INFLAMMATION; PREDICT MORTALITY; ORGAN FAILURE; SEVERE SEPSIS; CIRRHOSIS; CELLS;

D O I：

10.4049/jimmunol.1600818

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The acute-on-chronic liver failure (ACLF) syndrome is characterized by acute decompensation of cirrhosis, organ failure, and high 28-d mortality. ACLF displays key features of systemic inflammation and its poor outcome is closely associated with exacerbated systemic inflammatory responses. In this review, we describe the prevailing characteristics of systemic inflammation in patients with decompensated cirrhosis and ACLF, with special emphasis on the principal features of the cytokine storm the mechanisms underlying this intense systemic inflammatory response (i.e., presence of circulating pathogen-and damage-associated molecular patterns), and their implication in tissue and organ damage in this condition.

引用

页码：3755 / 3761

页数：7

共 68 条

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