Long-term lifestyle interventions in middle-aged and elderly men with nonalcoholic fatty liver disease: a randomized controlled trial

被引：43

作者：

Dong, Fangyuan ^{[1
,2
]}

Zhang, Yan ^{[1
,2
,3
]}

Huang, Yiqin ^{[1
,2
,3
]}

Wang, Yiqian ^{[1
]}

Zhang, Gansheng ^{[1
]}

Hu, Xiaona ^{[1
,2
]}

Wang, Jiaofeng ^{[2
,3
]}

Chen, Jie ^{[1
,2
,3
]}

Bao, Zhijun ^{[1
,2
,3
]}

机构：

[1] Fudan Univ, Shanghai Med Coll, Huadong Hosp, Dept Gastroenterol, 221 Yanan West Rd, Shanghai 200040, Peoples R China

[2] Shanghai Key Lab Clin Geriatr Med, 221 Yanan West Rd, Shanghai 200040, Peoples R China

[3] Fudan Univ, Res Ctr Aging & Med, 221 Yanan West Rd, Shanghai 200040, Peoples R China

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

关键词：

PHYSICAL-ACTIVITY; WEIGHT-LOSS; AMERICAN ASSOCIATION; PRACTICE GUIDELINE; DIAGNOSIS; STEATOHEPATITIS; METAANALYSIS; MANAGEMENT; ULTRASOUND; EXERCISE;

D O I：

10.1038/srep36783

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nonalcoholic fatty liver disease (NAFLD), a metabolic disorder related to insulin resistance and metabolic syndrome, has become a public health concern. Currently, the principal therapeutic modalities targeting NAFLD are lifestyle interventions. However, the efficacy of long-term lifestyle interventions in managing NAFLD remains largely unexplored. This study aimed to evaluate the efficacy of long-term lifestyle interventions in middle-aged and elderly men with NAFLD. All 280 eligible patients were randomized to the control or test group. Patients in the test group received counseling on diet and exercise from 2 physicians every 3 months via a phone call. Patients in the control group received only counseling in annual checkups without regular intervention. After the 2-year periodic intervention, body weight, abdominal circumference, ALT, TCH, LDL-C and HDL-C decreased in the test group. Specifically, the fatty liver index (FLI) and NAFLD-fibrosis score (NAFLD-FS) reduced markedly in the test group. However, in the control group, there was only a significant decrease in LDL-C, HDL-C and NAFLD-FS (P < 0.001). The liver steatosis grade of the test group decreased significantly, while it increased in the control group. In NAFLD, long-term lifestyle interventions exert an anti-obesity effect and attenuate liver dysfunction and steatosis.

引用

页数：8

共 34 条

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