Behavioral and molecular effects of prenatal continuous light exposure in the adult rat

被引：40

作者：

Voiculescu, Suzana Elena ^{[1
]}

Le Duc Diana ^{[2
,3
]}

Rosca, Adrian Eugen ^{[1
]}

Zeca, Vlad ^{[1
]}

Chitimus, Diana Maria ^{[1
]}

Arsene, Andreea Letitia ^{[4
]}

Dragoi, Cristina Manuela ^{[4
]}

Nicolae, Alina Crenguta ^{[4
]}

Zagrean, Leon ^{[1
]}

Schoeneberg, Torsten ^{[2
]}

Zagrean, Ana-Maria ^{[1
]}

机构：

[1] Carol Davila Univ Med & Pharm, Div Physiol & Fundamental Neurosci, 8 Eroii Sanit Blvd, Bucharest 050474, Romania

[2] Univ Leipzig, Fac Med, Inst Biochem, Mol Biochem, Johannisallee 30, D-04103 Leipzig, Germany

[3] Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany

[4] Carol Davila Univ Med & Pharm, Fac Pharm, Dept Biochem, Bucharest, Romania

来源：

BRAIN RESEARCH | 2016年 / 1650卷

关键词：

Prenatal continuous light exposure; Circadian rhythm; Anxiety; Memory; Serotonin; Melatonin; OXIDATIVE STRESS; PINEAL-GLAND; LIPID-PEROXIDATION; CIRCADIAN-RHYTHMS; SERUM MELATONIN; CONSTANT LIGHT; OPEN-FIELD; ANXIETY; BRAIN; MEMORY;

D O I：

10.1016/j.brainres.2016.08.031

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Disruption of the maternal environment during pregnancy leads to behavioral changes and diseases in the adult offspring. To explore the influence of prenatal continuous light exposure (PCLE) on the adult offspring, we exposed pregnant Wistar rats to constant light during late gestation. Adult PCLE offspring showed an anxiety-like behavior and impairment of short-term memory in different tests. Measurements in the whole brain homogenates from newborn and adult offspring indicated decreased melatonin and serotonin levels and increased reactive oxygen species level in PCLE offspring. Further, we determined melatonin-, serotonin-, oxidative stress-, apoptosis-, and circadian system-related genes expression in different brain areas of adult offspring. The serotonin reuptaker Slc6a4 displayed a decreased expression in the prefrontal cortex of PCLE group. The circadian rhythm-related gene Rora was upregulated in the amygdala of PCLE offspring. Our results point to adverse behavioral effects of PCLE on adult offspring, involving serotonin and melatonin signaling dysregulation, increased chronic oxidative stress, and altered gene expression. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：51 / 59

页数：9

共 69 条

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