No association between a polymorphism in the steroid metabolism gene CYP17 and risk of breast cancer

被引：90

作者：

Dunning, AM

Healey, CS

Pharoah, PDP

Foster, NA

Lipscombe, JM

Redman, KL

Easton, DF

Day, NE

Ponder, BAJ

机构：

[1] Addenbrookes Hosp, CRC, Human Canc Genet Res Grp, Cambridge CB2 2QQ, England

[2] Univ Cambridge, Dept Community Med, Strangeways Res Labs, Cambridge CB1 4RN, England

[3] Univ Cambridge, Genet Epidemiol Unit, CRC, Cambridge CB1 4RN, England

来源：

BRITISH JOURNAL OF CANCER | 1998年 / 77卷 / 11期

基金：

英国医学研究理事会;

关键词：

617 gene polymorphism; steroid metabolism; breast cancer;

D O I：

10.1038/bjc.1998.340

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A recent study showed an association between a single base substitution, T-->C, in the promotor region of the GYP17 gene, the risk of breast cancer and age at menarche in Asian, African-American and Latino women from California and Hawaii. The C allele was associated with increased risk of breast cancer, significantly so for patients presenting with advanced disease, whereas the TT genotype was associated with later age at menarche in control subjects. We attempted to confirm these findings in a large case-control study in East Anglia, England (835 cases and 591 control subjects). We found no evidence of an increased risk of breast cancer [odds ratio (OR) 1.10, confidence interval (Cl) 0.89-1.37] or advanced breast cancer (OR 0.88, CI 0.38-2.01) in C allele carriers, nor any association between age at menarche and genotype. We conclude that these alleles do not significantly alter breast cancer risk in the English population.

引用

页码：2045 / 2047

页数：3

共 5 条

[1]

CAREY AH, 1997, HUM MOL GENET, V10, P1873

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