Bio-monitoring of Tissue Accumulation and Genotoxic Effect of Heavy Metals in Cyprinus carpio from River Kabul Khyber Pakhtunkhwa Pakistan

被引：17

作者：

Siraj, Muhammad ^{[1
]}

Khisroon, Muhammad ^{[1
]}

Khan, Ajmal ^{[1
]}

Zaidi, Farrah ^{[1
]}

Ullah, Ahmad ^{[1
]}

Rahman, Ghani ^{[2
]}

机构：

[1] Univ Peshawar, Dept Zool, Peshawar, Khyber Pakhtunk, Pakistan

[2] Univ Gujrat, Dept Geog, Gujrat City, Pakistan

来源：

BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY | 2018年 / 100卷 / 03期

关键词：

Tissue accumulation; Heavy metals; Genotoxicity; Cyprinus carpio; River Kabul; COMET ASSAY; OXIDATIVE STRESS; WALLAGO-ATTU; INDUS RIVER; DNA-DAMAGE; BIOMARKERS;

D O I：

10.1007/s00128-017-2265-5

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The study explored (I) the concentration of heavy metals in water samples (II) their bioaccumulation in common carp Cyprinus carpio (III) and the subsequent genotoxicity in the selected organs of carp; from river Kabul, Khyber Pakhtunkhwa Pakistan. Except for Mercury (Hg) the water samples had all the heavy metals within permissible limits of recommended dietary allowance (RDA). Nonetheless a number of heavy metals (Zn, Ni, Cr, Cd, Pb and Hg) showed bioaccumulation at levels higher than permissible. Zinc (Zn) was the most while Cadmium (Cd) was the least accumulated metal in all tissue samples analyzed. The metal burden in different organs of C. carpio was in sequence of intestine > skin > liver > gills > muscle. The Comet assay established DNA damage in selected organs to be in accordance with metal burden; the most to least damage being in sequence of blood > intestine > skin > liver > gills > muscle. In conclusion assessment of DNA damage in the organs of C. carpio appears to be a useful bio-marker to evaluate genotoxic effects of heavy metal pollution.

引用

页码：344 / 349

页数：6

共 19 条

[1] The in vivo comet assay:: use and status in genotoxicity testing [J].

Brendler-Schwaab, S ;

Hartmann, A ;

Pfuhler, S ;

Speit, G .

MUTAGENESIS, 2005, 20 (04) :245-254

[2] Assessing metal, protein, and DNA profiles in Labeo rohita from the Indus River in Mianwali, Pakistan [J].

Chaudhry, Abdul Shakoor ;

Jabeen, Farhat .

ENVIRONMENTAL MONITORING AND ASSESSMENT, 2011, 174 (1-4) :665-679

[3] The comet assay for DNA damage and repair - Principles, applications, and limitations [J].

Collins, AR .

MOLECULAR BIOTECHNOLOGY, 2004, 26 (03) :249-261

[4]

Eisler R., 1993, US FISH WILDLIFE SER, P106

[5]

Geldiay R, 1988, FRESHWATER FISH SPEC, V97, P519

[6]

Holmes AL, 2008, INDIAN J MED RES, V128, P353

[7] Variation in genotoxic susceptibility and biomarker responses in Cirrhinus mrigala and Catla catla from different ecological niches of the Chenab River [J].

Hussain, Bilal ;

Sultana, Tayyaba ;

Sultana, Salma ;

Mahboob, Shahid ;

Al-Ghanim, K. A. ;

Nadeem, Shahid .

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2016, 23 (14) :14589-14599

[8] Toxicological study of the Anam river in Otuocha, Anambra state, Nigeria [J].

Igwilo, Innocent O. ;

Afonne, Onyenmechi Johnson ;

Maduabuchi, Ugwuona John-Moses ;

Orisakwe, Orish Ebere .

ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH, 2006, 61 (05) :205-208

[9]

Jabeen F, 2013, PAK J ZOOL, V45, P9

[10] Studies on biomarkers of oxidative stress and associated genotoxicity and histopathology in Channa punctatus from heavy metal polluted canal [J].

Javed, Mehjbeen ;

Ahmad, Irshad ;

Usmani, Nazura ;

Ahmad, Masood .

CHEMOSPHERE, 2016, 151 :210-219

← 1 2 →