Cardiotoxicity associated with the synthetic cannabinoid, K9, with laboratory confirmation

被引：83

作者：

Young, Amy C. ^{[1
]}

Schwarz, Evan ^{[1
]}

Medina, Genevieve ^{[2
]}

Obafemi, Adebisi ^{[3
]}

Feng, Sing-Yi ^{[4
]}

Kane, Colin ^{[4
]}

Kleinschmidt, Kurt ^{[1
]}

机构：

[1] Univ Texas SW, Dept Surg, Div Emergency Med, Dallas, TX USA

[2] Texas DPS Crime Lab, Dallas, TX USA

[3] N Texas Poison Ctr, Dallas, TX USA

[4] Univ Texas SW, Dept Pediat, Dallas, TX USA

来源：

AMERICAN JOURNAL OF EMERGENCY MEDICINE | 2012年 / 30卷 / 07期

关键词：

JWH-018;

D O I：

10.1016/j.ajem.2011.05.013

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Synthetic cannabinoids have been popular recreational drugs of abuse for their psychoactive properties. Five of the many synthetic cannabinoids have been recently banned in the United States because of their unknown and potentially harmful adverse effects. Little is known about these substances. They are thought to have natural cannabinoid-like effects but have different chemical structures. Adverse effects related to synthetic cannabinoids are not well known. We provide clinical effects and patient outcome following K9 use. In addition, we briefly review synthetic cannabinoids. We present a 17-year-old adolescent boy with chest pain, tachycardia, and then bradycardia associated with smoking K9. Two synthetic cannabinoids, JWH-018 and JWH-073, were confirmed on laboratory analysis. In addition to the limited current data, we demonstrate harmful adverse effects related to toxicity of 2 synthetic cannabinoids. Further studies are needed.

引用

页数：3

共 10 条

[1]

[Anonymous], 2010, HUFFINGTONPOST

[2] 'Spice' and other herbal blends: harmless incense or cannabinoid designer drugs? [J].

Auwaerter, Volker ;

Dresen, Sebastian ;

Weinmann, Wolfgang ;

Mueller, Michael ;

Puetz, Michael ;

Ferreiros, Nerea .

JOURNAL OF MASS SPECTROMETRY, 2009, 44 (05) :832-837

[3] The Endocannabinoid System and Pain [J].

Guindon, Josee ;

Hohmann, Andrea G. .

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2009, 8 (06) :403-421

[4]

MOLLER I, 2010, DRUG TEST ANAL

[5]

Schneir AB., 2010, Journal of Emergency Medicine

[6] Synthetic Δ-9-Tetrahydrocannabinol (Dronabinol) Can Improve the Symptoms of Schizophrenia [J].

Schwarcz, Glenn ;

Karajgi, Basawaraj ;

McCarthy, Richard .

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2009, 29 (03) :255-258

[7] Detection of JWH-018 metabolites in smoking mixture post-administration urine [J].

Sobolevsky, Tim ;

Prasolov, Ilya ;

Rodchenkov, Grigory .

FORENSIC SCIENCE INTERNATIONAL, 2010, 200 (1-3) :141-147

[8] Spice drugs as a new trend: Mode of action, identification and legislation [J].

Vardakou, I. ;

Pistos, C. ;

Spiliopoulou, Ch. .

TOXICOLOGY LETTERS, 2010, 197 (03) :157-162

[9] In vitro phase I metabolism of the synthetic cannabimimetic JWH-018 [J].

Wintermeyer, Annette ;

Moeller, Ines ;

Thevis, Mario ;

Juebner, Martin ;

Beike, Justus ;

Rothschild, Markus A. ;

Bender, Katja .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2010, 398 (05) :2141-2153

[10] Withdrawal Phenomena and Dependence Syndrome After the Consumption of "Spice Gold" [J].

Zimmermann, Ulrich S. ;

Winkelmann, Patricia R. ;

Pilhatsch, Max ;

Nees, Josef A. ;

Spanagel, Rainer ;

Schulz, Katja .

DEUTSCHES ARZTEBLATT INTERNATIONAL, 2009, 106 (27) :464-467

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