Prospective derivation and validation of early dynamic model for predicting outcome in patients with acute liver failure

被引:84
作者
Kumar, Ramesh [1 ]
Shalimar [1 ]
Sharma, Hanish [1 ]
Goyal, Rohit [1 ]
Kumar, Ajay [1 ]
Khanal, Shankar [2 ]
Prakash, Shyam [1 ]
Gupta, S. Datta [3 ]
Panda, Subrat Kumar [3 ]
Acharya, Subrat Kumar [1 ]
机构
[1] All India Inst Med Sci, Dept Gastroenterol, New Delhi 110029, India
[2] All India Inst Med Sci, Dept Biostat, New Delhi 110029, India
[3] All India Inst Med Sci, Dept Pathol, New Delhi 110029, India
关键词
FULMINANT HEPATIC-FAILURE; FREE GC-GLOBULIN; MELD SCORE; ALPHA-FETOPROTEIN; ARTERIAL AMMONIA; EARLY INDICATORS; KINGS-COLLEGE; PROGNOSIS; TRANSPLANTATION; CRITERIA;
D O I
10.1136/gutjnl-2011-301762
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Objective It is difficult to predict the outcome in patients with acute liver failure (ALF) using existing prognostic models. This study investigated whether early changes in the levels of dynamic variables can predict outcome better than models based on static baseline variables. Design 380 patients with ALF (derivation cohort n=244, validation cohort n=136) participated in a prospective observational study. The derivation cohort was used to identify predictors of mortality. The ALF early dynamic (ALFED) model was constructed based on whether the levels of predictive variables remained persistently high or increased over 3 days above the discriminatory cut-off values identified in this study. The model had four variables: arterial ammonia, serum bilirubin, international normalised ratio and hepatic encephalopathy >grade II. The model was validated in a cohort of 136 patients with ALF. Results The ALFED model demonstrated excellent discrimination with an area under the receiver operator characteristic curve of 0.91 in the derivation cohort and of 0.92 in the validation cohort. The model was well calibrated in both cohorts and showed a similar increase in mortality with increasing risk scores from 0 to 6. The performance of the ALFED model was superior to the King's College Hospital criteria and the Model for End stage Liver Disease score, even when their 3-day serial values were taken into consideration. An ALFED score of >= 4 had a high positive predictive value (85%) and negative predictive value (87%) in the validation cohort. Conclusion The ALFED model accurately predicted outcome in patients with ALF, which may be useful in clinical decision-making.
引用
收藏
页码:1068 / 1075
页数:8
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