Preparation and NMR spectroscopic studies of the glucuronides of Irbesartan

被引：12
作者：
Byard, SJ
Herbert, JM
机构：
[1] Sanofi Res, Dept Analyt Sci, Alnwick NE66 2JH, Northd, England
[2] Sanofi Res, Isotope Chem Labs, Alnwick NE66 2JH, Northd, England
[3] Sanofi Res, Dept Preclin Metab & Pharmacokinet, Alnwick NE66 2JH, Northd, England
来源：
TETRAHEDRON | 1999年 / 55卷 / 18期
关键词：
angiotensin II antagonist; tetrazole glucuronide; nOe enhancement; C-13/H-1; correlation;
D O I：
10.1016/S0040-4020(99)00255-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The preparation of N1- and N2-glucuronides of Irbesartan (SR47436) is described. The regiochemistry of the products was established from NMR spectroscopic studies, and the N2-glucuronide was identical to material obtained from natural sources. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：5931 / 5936
页数：6
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