Synthesis of Propargyl-Terminated Heterobifunctional Poly(ethylene glycol)

被引：15

作者：

Lu, Changhai ^{[1
]}

Zhong, Wen ^{[1
,2
]}

机构：

[1] Univ Manitoba, Fac Human Ecol, Dept Text Sci, Winnipeg, MB R3T 2N2, Canada

[2] Univ Manitoba, Fac Med, Dept Med Microbiol, Winnipeg, MB R3T 2N2, Canada

来源：

POLYMERS | 2010年 / 2卷 / 04期

基金：

加拿大自然科学与工程研究理事会;

关键词：

heterobifunctional; poly(ethylene glycol); click" chemistry;

D O I：

10.3390/polym2040407

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Novel propargyl-ended heterobifunctional poly(ethylene glycol) (PEG) derivatives with hydroxyl, carboxyl, mercapto or hydrazide end groups were synthesized with simplicity yet high efficiency. PEG (M-w = 3500 Da) with an alpha-hydroxyl group and an omega-carboxyl was used as the starting polymer. The carboxyl group of the bifunctional PEG was modified into a propargyl, then carboxyl, mercapto or hydrazide groups were introduced to the other end of the bifunctional PEG by modifying the bifunctional PEG's hydroxyl group with succinic anhydride, cysteamide or tert-butyl carbazate, respectively. This method can be useful to the development of PEG-based bioconjugates for a variety of biomedical applications.

引用

页码：407 / 417

页数：11

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