Anti-Helicobacter pylori activity of the metabolites of poncirin from Poncirus trifoliata by human intestinal bacteria

被引：1
作者：
Kim, DH
Bae, EA
Han, MJ
机构：
[1] Kyung Hee Univ, Coll Pharm, Seoul 130701, South Korea
[2] Kyung Hee Univ, Dept Food & Nutr, Seoul 130701, South Korea
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 1999年 / 22卷 / 04期
关键词：
Helicobacter pylori; Poncirus trifoliata; 5,7-dihydroxy-4 '-methoxyflavanone;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Poncirin Has isolated from water extract of the fruits of Poncirus trifoliata and metabolized by human intestinal bacteria. The inhibitory effect of poncirin and its metabolites by these bacteria on the growth of Helicobacter pylori (HP) was investigated. Among them, ponciretin (5,7-dihydroxy-4'-methoxyflavanone), the main metabolite most potently inhibited the growth of HP, with a minimum inhibitory concentration (MIC) of 10-20 20 mu g/ml. However, poncirin and its metabolites ercept ponciretin did not inhibit the growth of HP, nor did they inhibit HP urease.
引用
收藏
页码：422 / 424
页数：3
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