Cohesin, CTCF and lymphocyte antigen receptor locus rearrangement

被引：23
作者：
Seitan, Vlad C. [1 ]
Krangel, Michael S. [2 ]
Merkenschlager, Matthias [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, MRC Clin Sci Ctr, Lymphocyte Dev Grp, London W12 0NN, England
[2] Duke Univ, Med Ctr, Dept Immunol, Durham, NC USA
来源：
TRENDS IN IMMUNOLOGY | 2012年 / 33卷 / 04期
基金：
英国医学研究理事会;
关键词：
cohesin; CTCF; transcription; recombination; HEAVY-CHAIN GENE; CCCTC-BINDING FACTOR; PRO-B CELLS; V(D)J RECOMBINATION; NUCLEAR-ORGANIZATION; IMMUNOGLOBULIN LOCI; ALLELIC EXCLUSION; IGH LOCUS; TRANSCRIPTION; ARCHITECTURE;
D O I：
10.1016/j.it.2012.02.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The somatic recombination of lymphocyte antigen receptor loci is integral to lymphocyte differentiation and adaptive immunity. Here we review the relation of this highly choreographed process with the zinc finger protein CTCF and with cohesin, a protein complex best known for its essential functions in post-replicative DNA repair and chromosome segregation during the cell cycle. At lymphocyte antigen receptor loci, CTCF and cohesin shape long-range interactions and contribute to V(D)J recombination by facilitating lineage- and developmental-stage-specific transcription and accessibility.
引用
收藏
页码：153 / 159
页数：7
相关论文
共 30 条
[1]   The epigenetic role of non-coding RNA transcription and nuclear organization in immunoglobulin repertoire generation [J].
Corcoran, Anne E. .
SEMINARS IN IMMUNOLOGY, 2010, 22 (06) :353-361
[2]   The DNA-Binding Protein CTCF Limits Proximal Vκ Recombination and Restricts κ Enhancer Interactions to the Immunoglobulin κ Light Chain Locus [J].
de Almeida, Claudia Ribeiro ;
Stadhouders, Ralph ;
de Bruijn, Marjolein J. W. ;
Bergen, Ingrid M. ;
Thongjuea, Supat ;
Lenhard, Boris ;
van IJcken, Wilfred ;
Grosveld, Frank ;
Galjart, Niels ;
Soler, Eric ;
Hendriks, Rudi W. .
IMMUNITY, 2011, 35 (04) :501-513
[3]   CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells [J].
Degner, Stephanie C. ;
Verma-Gaur, Jiyoti ;
Wong, Timothy P. ;
Bossen, Claudia ;
Iverson, G. Michael ;
Torkamani, Ali ;
Vettermann, Christian ;
Lin, Yin C. ;
Ju, Zhongliang ;
Schulz, Danae ;
Murre, Caroline S. ;
Birshtein, Barbara K. ;
Schork, Nicholas J. ;
Schlissel, Mark S. ;
Riblet, Roy ;
Murre, Cornelis ;
Feeney, Ann J. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (23) :9566-9571
[4]   Cutting Edge: Developmental Stage-Specific Recruitment of Cohesin to CTCF Sites throughout Immunoglobulin Loci during B Lymphocyte Development [J].
Degner, Stephanie C. ;
Wong, Timothy P. ;
Jankevicius, Gytis ;
Feeney, Ann J. .
JOURNAL OF IMMUNOLOGY, 2009, 182 (01) :44-48
[5]   Epigenetic and 3-dimensional regulation of V(D)J rearrangement of immunoglobulin genes [J].
Degner-Leisso, Stephanie C. ;
Feeney, Ann J. .
SEMINARS IN IMMUNOLOGY, 2010, 22 (06) :346-352
[6]   The Distal VH Gene Cluster of the Igh Locus Contains Distinct Regulatory Elements with Pax5 Transcription Factor-Dependent Activity in Pro-B Cells [J].
Ebert, Anja ;
McManus, Shane ;
Tagoh, Hiromi ;
Medvedovic, Jasna ;
Salvagiotto, Giorgia ;
Novatchkova, Maria ;
Tamir, Ido ;
Sommer, Andreas ;
Jaritz, Markus ;
Busslinger, Meinrad .
IMMUNITY, 2011, 34 (02) :175-187
[7]   The Mouse Immunoglobulin Heavy Chain V-D Intergenic Sequence Contains Insulators That May Regulate Ordered V(D)J Recombination [J].
Featherstone, Karen ;
Wood, Andrew L. ;
Bowen, Adam J. ;
Corcoran, Anne E. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (13) :9327-9338
[8]   Nuclear organization of the genome and the potential for gene regulation [J].
Fraser, Peter ;
Bickmore, Wendy .
NATURE, 2007, 447 (7143) :413-417
[9]   Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene [J].
Fuxa, M ;
Skok, J ;
Souabni, A ;
Salvagiotto, G ;
Roldan, E ;
Busslinger, M .
GENES & DEVELOPMENT, 2004, 18 (04) :411-422
[10]   Two Forms of Loops Generate the Chromatin Conformation of the Immunoglobulin Heavy-Chain Gene Locus [J].
Guo, Changying ;
Gerasimova, Tatiana ;
Hao, Haiping ;
Ivanova, Irina ;
Chakraborty, Tirtha ;
Selimyan, Roza ;
Oltz, Eugene M. ;
Sen, Ranjan .
CELL, 2011, 147 (02) :332-343
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