One-pot, regioselective synthesis of functionalized indole derivatives: a three-component domino reaction of arylamine, arylglyoxal, and 4-hydroxycoumarin or 4-hydroxy-6-methyl-2-pyrone

被引：5

作者：

Mehrabi, Hossein ^{[1
]}

Dastouri, Fatemeh ^{[1
]}

Asadi, Sara ^{[1
]}

Alizadeh-Bami, Farzaneh ^{[1
]}

Ranjbar-Karimi, Reza ^{[1
]}

机构：

[1] Vali E Asr Univ Rafsanjan, Dept Chem, Rafsanjan 77176, Iran

来源：

ARKIVOC | 2020年

关键词：

Arylamine; Arylglyoxal; 4-Hydroxycoumarin; 4-Hydroxy-6-methyl-2-pyrone; Functionalized indole derivatives; ANTIBACTERIAL; ANTIOXIDANT; ANTICANCER; EFFICIENT; ALKALOIDS;

D O I：

10.24820/ark.5550190.p011.151

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal free, one-pot tandem synthetic routes for functionalized indole derivatives has been established. An efficient three-component reaction was designed with incorporation of Knoevenagel condensation followed by inter-, and intramolecular nucleophilic addition reaction in one-pot under mild condition. The structural diversities of the synthesized compounds have been confirmed spectroscopically, by IR, H-1- and C-13 NMR, and elemental analyses which agree with the proposed structures. [GRAPHICS] .

引用

页码：114 / 125

页数：12

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