Epigenetic regulation of antagonistic receptors confers rice blast resistance with yield balance

被引：611

作者：

Deng, Yiwen ^{[1
,2
]}

Zhai, Keran ^{[1
,2
,3
]}

Xie, Zhen ^{[4
]}

Yang, Dongyong ^{[1
,2
,3
]}

Zhu, Xudong ^{[5
]}

Liu, Junzhong ^{[1
,2
]}

Wang, Xin ^{[1
,2
]}

Qin, Peng ^{[6
]}

Yang, Yuanzhu ^{[6
]}

Zhang, Guomin ^{[7
]}

Li, Qun ^{[1
,2
]}

Zhang, Jianfu ^{[8
]}

Wu, Shuangqing ^{[9
]}

Milazzo, Jolle ^{[10
]}

Mao, Bizeng ^{[4
]}

Wang, Ertao ^{[1
,2
]}

Xie, Huaan ^{[8
]}

Tharreau, Didier ^{[10
]}

He, Zuhua ^{[1
,2
,4
,11
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Plant Physiol & Ecol, Natl Key Lab Plant Mol Genet, Shanghai, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Plant Physiol & Ecol, Natl Ctr Plant Gene Res, Shanghai, Peoples R China

[3] Univ Chinese Acad Sci, Beijing, Peoples R China

[4] Zhejiang Univ, Coll Agr & Biotechnol, Hangzhou, Zhejiang, Peoples R China

[5] China Natl Rice Res Inst, State Key Lab Rice Biol, Hangzhou, Zhejiang, Peoples R China

[6] Sci Acad Hunan, State Key Lab Hybrid Rice & Yahua Seeds, Changsha, Hunan, Peoples R China

[7] Heilongjiang Acad Agr Sci, Harbin, Peoples R China

[8] Fujian Acad Agr Sci, Fuzhou, Peoples R China

[9] Enshi Tujia & Miao Autonomous Prefecture Acad Agr, Enshi, Peoples R China

[10] CIRAD Ctr Cooperat Int Rech Agronom Dev, UMR BGPI Biol & Genet Interact Plante Parasite, Montpellier, France

[11] Chinese Acad Sci, Collaborat Innovat Ctr Genet & Dev, Shanghai Inst Plant Physiol & Ecol, Shanghai 200032, Peoples R China

来源：

SCIENCE | 2017年 / 355卷 / 6328期

基金：

中国国家自然科学基金;

关键词：

DISEASE RESISTANCE; TRANSPOSABLE ELEMENTS; DNA METHYLATION; GENE; PROTEIN; POLLEN; SYSTEM; PI9;

D O I：

10.1126/science.aai8898

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Crop breeding aims to balance disease resistance with yield; however, single resistance (R) genes can lead to resistance breakdown, and R gene pyramiding may affect growth fitness. Here we report that the rice Pigm locus contains a cluster of genes encoding nucleotide-binding leucine-rich repeat (NLR) receptors that confer durable resistance to the fungus Magnaporthe oryzae without yield penalty. Among these NLR receptors, PigmR confers broad-spectrum resistance, whereas PigmS competitively attenuates PigmR homodimerization to suppress resistance. PigmS expression, and thus PigmR-mediated resistance, are subjected to tight epigenetic regulation. PigmS increases seed production to counteract the yield cost induced by PigmR. Therefore, our study reveals a mechanism balancing high disease resistance and yield through epigenetic regulation of paired antagonistic NLR receptors, providing a tool to develop elite crop varieties.

引用

页码：962 / 965

页数：4

共 26 条

[1] Defensin-Like ZmES4 Mediates Pollen Tube Burst in Maize via Opening of the Potassium Channel KZM1
Amien, Suseno
Kliwer, Irina
Marton, Mihaela L.
Debener, Thomas
Geiger, Dietmar
Becker, Dirk
Dresselhaus, Thomas
[J]. PLOS BIOLOGY, 2010, 8 (06)
[2] Structural and Functional Analysis of a Plant Resistance Protein TIR Domain Reveals Interfaces for Self-Association, Signaling, and Autoregulation
Bernoux, Maud
Ve, Thomas
Williams, Simon
Warren, Christopher
Hatters, Danny
Valkov, Eugene
Zhang, Xiaoxiao
Ellis, Jeffrey G.
Kobe, Bostjan
Dodds, Peter N.
[J]. CELL HOST & MICROBE, 2011, 9 (03) : 200 - 211
[3] A cost of disease resistance: paradigm or peculiarity?
Brown, JKM
[J]. TRENDS IN GENETICS, 2003, 19 (12) : 667 - 671
[4] The barley mlo gene: A novel control element of plant pathogen resistance
Buschges, R
Hollricher, K
Panstruga, R
Simons, G
Wolter, M
Frijters, A
vanDaelen, R
vanderLee, T
Diergaarde, P
Groenendijk, J
Topsch, S
Vos, P
Salamini, F
Schulze-Lefert, P
[J]. CELL, 1997, 88 (05) : 695 - 705
[5] Reprogramming of DNA Methylation in Pollen Guides Epigenetic Inheritance via Small RNA
Calarco, Joseph P.
Borges, Filipe
Donoghue, Mark T. A.
Van Ex, Frederic
Jullien, Pauline E.
Lopes, Telma
Gardner, Rui
Berger, Frederic
Feijo, Jose A.
Becker, Joerg D.
Martienssen, Robert A.
[J]. CELL, 2012, 151 (01) : 194 - 205
[6] Epigenetic regulation and functional exaptation of transposable elements in higher plants
Cui, Xiekui
Cao, Xiaofeng
[J]. CURRENT OPINION IN PLANT BIOLOGY, 2014, 21 : 83 - 88
[7] Pivoting the Plant Immune System from Dissection to Deployment
Dangl, Jeffery L.
Horvath, Diana M.
Staskawicz, Brian J.
[J]. SCIENCE, 2013, 341 (6147) : 746 - 751
[8] Disease resistance or growth: the role of plant hormones in balancing immune responses and fitness costs
Denance, Nicolas
Sanchez-Vallet, Andrea
Goffner, Deborah
Molina, Antonio
[J]. FRONTIERS IN PLANT SCIENCE, 2013, 4
[9] Genetic characterization and fine mapping of the blast resistance locus Pigm(t) tightly linked to Pi2 and Pi9 in a broad-spectrum resistant Chinese variety
Deng, Yiwen
Zhu, Xudong
Shen, Ying
He, Zuhua
[J]. THEORETICAL AND APPLIED GENETICS, 2006, 113 (04) : 705 - 713
[10] Widespread dynamic DNA methylation in response to biotic stress
Dowen, Robert H.
Pelizzola, Mattia
Schmitz, Robert J.
Lister, Ryan
Dowen, Jill M.
Nery, Joseph R.
Dixon, Jack E.
Ecker, Joseph R.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (32) : E2183 - E2191

← 1 2 3 →