Synthesis of 3H-Pyrazolo[3,4-c]isoquinolines and Thieno[3,2-c]isoquinolines via Cascade Imination/Intramolecular Decarboxylative Coupling

被引:31
作者
Pandey, Garima [1 ]
Bhowmik, Subhendu [1 ]
Batra, Sanjay [1 ,2 ]
机构
[1] CSIR Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226031, Uttar Pradesh, India
[2] Acad Sci & Innovat Res, New Delhi, India
关键词
HETEROAROMATIC CARBOXYLIC-ACIDS; BIARYL SYNTHESIS; AROMATIC CARBOXYLATES; DIRECT ARYLATION; TRANSFORMATIONS; PALLADATION;
D O I
10.1021/ol4023722
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A general approach for the synthesis of 3H-pyrazolo[3,4-c]isoquinolines and thieno[3,2-c]isoquinolines Is described involving the implementation of a cascade imination/intramolecular decarboxylative coupling between potassium 2"amino(hetero)benzoates and 2-haloarylaldehydes. The reactions of pyrazole-based substrates require a Pd-Cu bimetallic system for superior yields whereas the thienyl-based substrates afford the products in excellent yields with a Pd-catalyst only.
引用
收藏
页码:5044 / 5047
页数:4
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