Clinical Portrait of the SARS-CoV-2 Epidemic in European Patients with Cancer

被引：153

作者：

Pinato, David J. ^{[1
]}

Zambelli, Alberto ^{[2
]}

Aguilar-Company, Juan ^{[3
,4
,5
]}

Bower, Mark ^{[6
,7
]}

Sng, Christopher C. T. ^{[8
]}

Salazar, Ramon ^{[9
]}

Bertuzzi, Alexia ^{[10
]}

Brunet, Joan ^{[11
]}

Mesia, Ricard ^{[12
]}

Segui, Elia ^{[13
]}

Biello, Federica ^{[14
,15
]}

Generali, Daniele ^{[16
,17
]}

Grisanti, Salvatore ^{[18
]}

Rizzo, Gianpiero ^{[19
]}

Libertini, Michela ^{[20
]}

Maconi, Antonio ^{[21
]}

Harbeck, Nadia ^{[22
,23
,24
]}

Vincenzi, Bruno ^{[25
]}

Bertulli, Rossella ^{[26
]}

Ottaviani, Diego ^{[8
]}

Carbo, Anna ^{[11
]}

Bruna, Riccardo ^{[15
,27
]}

Benafif, Sarah ^{[8
]}

Marrari, Andrea ^{[10
]}

Wuerstlein, Rachel ^{[22
,23
,24
]}

Carmona-Garcia, M. Carmen ^{[11
]}

Chopra, Neha ^{[8
]}

Tondini, Carlo ^{[2
]}

Mirallas, Oriol ^{[3
,4
]}

Tovazzi, Valeria ^{[18
]}

Betti, Marta ^{[21
]}

Provenzano, Salvatore ^{[26
]}

Fotia, Vittoria ^{[2
]}

Cruz, Claudia Andrea ^{[13
]}

Dalla Pria, Alessia ^{[6
,7
]}

D'Avanzo, Francesca ^{[14
,15
]}

Evans, Joanne S. ^{[1
]}

Saoudi-Gonzalez, Nadia ^{[3
,4
]}

Felip, Eudald ^{[12
]}

Galazi, Myria ^{[8
]}

Garcia-Fructuoso, Isabel ^{[11
]}

Lee, Alvin J. X. ^{[8
]}

Newsom-Davis, Thomas ^{[6
,7
]}

Patriarca, Andrea ^{[15
,27
]}

Garcia-Illescas, David ^{[3
,4
]}

Reyes, Roxana ^{[13
]}

Dileo, Palma ^{[8
]}

Sharkey, Rachel ^{[6
,7
]}

Wong, Yien Ning Sophia ^{[8
]}

Ferrante, Daniela ^{[28
,29
]}

机构：

[1] Imperial Coll London, Hammersmith Hosp, Dept Surg & Canc, London, England

[2] ASST Papa Giovanni XXIII, Oncol Unit, Bergamo, Italy

[3] Vall dHebron Univ Hosp, Med Oncol, Barcelona, Spain

[4] Inst Oncol VHIO, Barcelona, Spain

[5] Vall dHebron Univ Hosp, Infect Dis, Barcelona, Spain

[6] Chelsea & Westminster Hosp, Dept Oncol, London, England

[7] Chelsea & Westminster Hosp, Natl Ctr HIV Malignancy, London, England

[8] Univ Coll London Hosp, Canc Div, London, England

[9] CIBERONC, Oncobell Program IDIBELL, Dept Med Oncol, ICO Hosp, Barcelona, Spain

[10] Humanitas Clin & Res Ctr IRCCS, Med Oncol & Hematol Unit, Humanitas Canc Ctr, Milan, Italy

[11] Univ Hosp Josep Trueta, Catalan Inst Oncol, Dept Med Oncol, Girona, Spain

[12] Catalan Inst Oncol, Dept Med Oncol, Badalona, Spain

[13] Hosp Clin Barcelona, Dept Med Oncol, Barcelona, Spain

[14] Univ Piemonte Orientale, Dept Translat Med, Div Oncol, Novara, Italy

[15] Maggiore Carita Hosp, Novara, Italy

[16] ASST Cremona, Multidisciplinary Breast Pathol & Translat Res Un, Cremona, Italy

[17] Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy

[18] Spedali Civil Brescia, Med Oncol Unit, Brescia, Italy

[19] Fdn IRCCS Policlin San Matteo, Med Oncol Unit, Pavia, Italy

[20] Fdn Poliambulanza Ist Osped, Med Oncol Unit, Brescia, Italy

[21] Azienda Osped SS Antonio & Biagio & Cesare Arrigo, Infrastruttura Ric Formaz Innovaz, Alessandria, Italy

[22] Univ Hosp Munich, Dept Gynecol & Obstet, Breast Ctr, Munich, Germany

[23] Univ Hosp Munich, Gynecol Canc Ctr, Munich, Germany

[24] Univ Hosp Munich, CCC Munich, Munich, Germany

[25] Policlin Univ Campus Biomed, Rome, Italy

[26] Fdn IRCCS Ist Nazl Tumori, Milan, Italy

[27] Univ Piemonte Orientale, Div Haematol, Dept Translat Med, Novara, Italy

[28] Univ Piemonte Orientale, Dept Translat Med, Unit Med Stat, Novara, Italy

[29] CPO Piemonte, Canc Epidemiol, Novara, Italy

[30] Hosp Clin Barcelona, Dept Internal Med, Barcelona, Spain

[31] Univ Barcelona, Haematol Dept, ICO Hosp, IDIBELL, Barcelona, Spain

[32] Humanitas Univ, Dept Biomed Sci, Milan, Italy

[33] Vall dHebron Univ Hosp, Dept Haematol, Barcelona, Spain

[34] IDIBAPS, Translat Genom & Targeted Therapies Solid Tumors, Barcelona, Spain

来源：

CANCER DISCOVERY | 2020年 / 10卷 / 10期

基金：

英国惠康基金;

关键词：

D O I：

10.1158/2159-8290.CD-20-0773

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The SARS-CoV-2 pandemic significantly affected oncology practice across the globe. There is uncertainty as to the contribution of patients' demographics and oncologic features to severity and mortality from COVID-19 and little guidance as to the role of anti-cancer and anti-COVID-19 therapy in this population. In a multicenter study of 890 patients with cancer with confirmed COVID-19, we demonstrated a worsening gradient of mortality from breast cancer to hematologic malignancies and showed that male gender, older age, and number of comorbidities identify a subset of patients with significantly worse mortality rates from COVID-19. Provision of chemotherapy, targeted therapy, or immunotherapy did not worsen mortality. Exposure to antimalarials was associated with improved mortality rates independent of baseline prognostic factors. This study highlights the clinical utility of demographic factors for individualized risk stratification of patients and supports further research into emerging anti-COVID-19 therapeutics in SARS-CoV-2-infected patients with cancer. SIGNIFICANCE: In this observational study of 890 patients with cancer diagnosed with SARS-CoV-2, mortality was 33.6% and predicted by male gender, age >= 65, and comorbidity burden. Delivery of cancer therapy was not detrimental to severity or mortality from COVID-19. These patients should be the focus of shielding efforts during the SARS-CoV-2 pandemic.

引用

页码：1465 / 1474

页数：10

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