Five new flavonoid glycosides from Nervilia fordii

被引：24

作者：

Qiu, Li ^{[1
,2
,3
]}

Jiao, Yang ^{[3
]}

Xie, Ji-Zhao ^{[3
]}

Huang, Gui-Kun ^{[3
]}

Qiu, Shao-Ling ^{[3
]}

Miao, Jian-Hua ^{[2
]}

Yao, Xin-Sheng ^{[1
]}

机构：

[1] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

[2] Inst Guangxi Med Plant, Nanning 530023, Peoples R China

[3] Guangxi Med Univ, Sch Pharmaceut Sci, Nanning 530021, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2013年 / 15卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Nervilia; fordii; flavonoid glycosides; anti-inflammatory; NO release inhibition; C-GLYCOSIDES; CHEMICAL-CONSTITUENTS; PLANT;

D O I：

10.1080/10286020.2013.790377

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new flavonoid glycosides, namely nervilifordins F-J (1-5), were isolated from the 60% EtOH extract of the aerial parts of Nerviliafordii, along with three first isolated flavonoids (7, 8, and 13) and five known flavonoids (6, 9-12). The structures of new compounds were elucidated on the basis of 1D and 2D NMR and MS studies. Their anti-inflammatory activities were tested by measuring their inhibitory effects on nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages. Compounds 2 and 5 showed interesting inhibition effects with their EC50 values of 15.15M and 14.80M, respectively.

引用

页码：589 / 599

页数：11

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