Interaction of tumor-associated macrophages and cancer chemotherapy

被引：242
作者：
Larionova, Irina [1 ,2 ]
Cherdyntseva, Nadezhda [1 ,2 ]
Liu, Tengfei [3 ]
Patysheva, Marina [2 ]
Rakina, Militsa [1 ]
Kzhyshkowska, Julia [1 ,3 ,4 ]
机构：
[1] Natl Res Tomsk State Univ, Lab Translat Cellular & Mol Biomed, Tomsk, Russia
[2] Russian Acad Sci, Tomsk Natl Res Med Ctr, Canc Res Inst, Lab Mol Oncol & Immunol, Tomsk, Russia
[3] Heidelberg Univ, Med Fac Mannheim, Inst Transfus Med & Immunol, Dept Innate Immun & Tolerance, Mannheim, Germany
[4] German Red Cross Blood Serv Baden Wurttemberg Hes, Mannheim, Germany
来源：
ONCOIMMUNOLOGY | 2019年 / 8卷 / 07期
基金：
俄罗斯科学基金会;
关键词：
Tumor-associated macrophages; cancer chemotherapy; chemoresistance; immunomodulation; tumor progression; immune system; MURINE PERITONEAL-MACROPHAGES; SERUM YKL-40 LEVEL; BREAST-CANCER; INFILTRATING MACROPHAGES; POOR-PROGNOSIS; CATHEPSIN-B; CYTOTOXIC CHEMOTHERAPY; POLARIZED MACROPHAGES; CYSTEINE CATHEPSINS; DRUG-RESISTANCE;
D O I：
10.1080/2162402X.2019.1596004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
It has been recently recognized that the tumor microenvironment (TME) is an essential factor that defines the efficiency of chemotherapy. The local TME, consisting of immune cells with diverse phenotypes and functions, can strongly modulate the response to chemotherapy. Tumor-associated macrophages (TAMs) that display pronounced heterogeneity and phenotypic plasticity are the major innate immune component in the microenvironment of solid tumors. In our review, we elucidate the complex role of TAMs in the progression of different types of solid tumors, summarize the current knowledge about the effects of different anticancer chemotherapeutic agents on monocytes/macrophages, and describe the mechanisms of chemotherapy resistance mediated by TAMs.
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页数：15
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