Amino oxazolines as a new class of organocatalyst for the direct intermolecular asymmetric aldol reaction between acetone and aromatic aldehydes

被引：12

作者：

Saiyed, Akeel S. ^{[1
]}

Bedekar, Ashutosh V. ^{[1
]}

机构：

[1] Maharaja Sayajirao Univ Baroda, Fac Sci, Dept Chem, Vadodara 390002, Gujarat, India

来源：

TETRAHEDRON-ASYMMETRY | 2013年 / 24卷 / 17期

关键词：

ENANTIOSELECTIVE SYNTHESIS; CARBONYL-COMPOUNDS; MICHAEL ADDITION; KETONES; TETRAZOLE; LIGANDS; ACIDS; ARYL;

D O I：

10.1016/j.tetasy.2013.07.020

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of chiral amino oxazolines were synthesized and screened as organocatalysts for asymmetric intermolecular aldol reactions between acetone and aromatic aldehydes. The reaction works well with a range of aromatic aldehydes showing good to high selectivity. The present new system of the organocatalyst was effective for the asymmetric aldol reaction for a wide range of aromatic aldehydes and isatin to carry out an asymmetric carbon-carbon bond forming reaction with a high enantioselectivity of up to 91%. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：1035 / 1041

页数：7

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