Feasibility of tomotherapy to reduce cochlea radiation dose in patients with locally advanced nasopharyngeal cancer

被引：0

作者：

Nguyen, Nam P. ^{[1
]}

Ceizyk, Misty ^{[1
]}

Vinh-Hung, Vincent ^{[2
]}

Sroka, Thomas ^{[1
]}

Jang, Siyoung ^{[1
]}

Khan, Rihan ^{[3
]}

Locke, Angela ^{[1
]}

Albala, Gabby ^{[1
]}

Truong, Christina ^{[1
]}

Godinez, Juan ^{[4
]}

Vos, Richard ^{[5
]}

Smith-Raymond, Lexie ^{[1
]}

机构：

[1] Univ Arizona, Dept Radiat Oncol, Tucson, AZ 85724 USA

[2] Univ Arizona, Dept Radiol, Tucson, AZ 85724 USA

[3] Univ Hosp Geneva, Dept Radiat Oncol, Geneva, Switzerland

[4] Florida Radiat Oncol Grp, Palatka, FL USA

[5] Univ Galveston, Sch Med, Galveston, TX USA

来源：

TUMORI JOURNAL | 2012年 / 98卷 / 06期

关键词：

nasopharyngeal cancer; tomotherapy; image guided radiation therapy; cochlea sparing; INTENSITY-MODULATED RADIOTHERAPY; SENSORINEURAL HEARING-LOSS; HELICAL TOMOTHERAPY; INNER-EAR; CARCINOMA; THERAPY; HEAD; CHEMORADIOTHERAPY; CHEMOTHERAPY; CISPLATIN;

D O I：

10.1177/030089161209800606

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aims and background. To evaluate the effectiveness of tomotherapy-based image-guided radiotherapy (IGRT) on the radiation dose to the cochlea in patients with nasopharyngeal cancer. Methods and study design. A retrospective review of five patients undergoing concurrent chemoradiation with tomotherapy for locally advanced nasopharyngeal cancer was performed. Results. The mean dose to the right and left cochlea was 25 Gy and 35.3 Gy respectively, while the dose to the gross tumor ranged from 70 to 75 Gy. All patients had excellent clinical response to the treatment at a median follow-up of five months. Conclusions. IGRT for head and neck cancer delivered by tomotherapy can significantly decrease the radiation dose to the cochlea without sacrificing target volume coverage.

引用

页码：709 / 714

页数：6

共 25 条

[1] Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: Phase III randomized intergroup study 0099 [J].

Al-Sarraf, M ;

LeBlanc, M ;

Giri, PGS ;

Fu, KK ;

Cooper, J ;

Vuong, T ;

Forastiere, AA ;

Adams, G ;

Sakr, WA ;

Schuller, DE ;

Ensley, JF .

JOURNAL OF CLINICAL ONCOLOGY, 1998, 16 (04) :1310-1317

[2] Is tomotherapy the future of IMRT? [J].

Beavis, AW .

BRITISH JOURNAL OF RADIOLOGY, 2004, 77 (916) :285-295

[3] SENSORINEURAL HEARING LOSS AFTER TREATMENT OF NASOPHARYNGEAL CARCINOMA: A LONGITUDINAL ANALYSIS [J].

Chan, S. H. ;

Ng, W. T. ;

Kam, K. L. ;

Lee, Michael C. H. ;

Choi, C. W. ;

Yau, T. K. ;

Lee, Anne W. M. ;

Chow, S. K. .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2009, 73 (05) :1335-1342

[4] A split-organ delineation approach for dose optimisation for intensity-modulated radiotherapy for advanced T-stage nasopharyngeal carcinoma [J].

Chau, R. M. C. ;

Leung, S. F. ;

Kam, M. K. M. ;

Cheung, K. Y. ;

Kwan, W. H. ;

Yu, K. H. ;

Chiu, S. K. W. ;

Chan, A. T. C. .

CLINICAL ONCOLOGY, 2008, 20 (02) :134-141

[5] Comparison of Intensity-Modulated Radiotherapy Using Helical Tomotherapy and Segmental Multileaf Collimator-based Techniques for Nasopharyngeal Carcinoma: Dosimetric Analysis Incorporating Quality Assurance Guidelines from RTOG 0225 [J].

Chen, Allen M. ;

Lee, Nancy Y. ;

Yang, Claus C. ;

Liu, Tianxiao ;

Narayan, Samir ;

Vijayakumar, Srinivasan ;

Purdy, James A. .

TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2010, 9 (03) :291-298

[6] Sensorineural hearing loss in combined modality treatment of nasopharyngeal carcinoma [J].

Chen, WC ;

Jackson, A ;

Budnick, AS ;

Pfister, DG ;

Kraus, DH ;

Hunt, MA ;

Stambuk, H ;

Levegrun, S ;

Wolden, SL .

CANCER, 2006, 106 (04) :820-829

[7]

Chen WW, 2011, CANCER, V117, P1874

[8] Cisplatin and Oxaliplatin Toxicity: Importance of Cochlear Kinetics as a Determinant for Ototoxicity [J].

Hellberg, Victoria ;

Wallin, Inger ;

Eriksson, Sofi ;

Hernlund, Emma ;

Jerremalm, Elin ;

Berndtsson, Maria ;

Eksborg, Staffan ;

Arner, Elias S. J. ;

Shoshan, Maria ;

Ehrsson, Hans ;

Laurell, Goran .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2009, 101 (01) :37-47

[9] RELATIVE CONTRIBUTIONS OF RADIATION AND CISPLATIN-BASED CHEMOTHERAPY TO SENSORINEURAL HEARING LOSS IN HEAD-AND-NECK CANCER PATIENTS [J].

Hitchcock, Ying J. ;

Tward, Jonathan D. ;

Szabo, Aniko ;

Bentz, Brandon G. ;

Shrieve, Dennis C. .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2009, 73 (03) :779-788

[10] Intensity-modulated radiation therapy for pediatric medulloblastoma: Early report on the reduction of ototoxicity [J].

Huang, E ;

Strother, DR ;

Davis, QG ;

Chiu, JK ;

Lu, HH ;

Carpenter, LS ;

Mai, WY ;

Chintagumpala, MM ;

South, M ;

Grant, WH ;

Butler, EB ;

Woo, SY .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2002, 52 (03) :599-605

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