Step-Index Optical Fiber Made of Biocompatible Hydrogels

被引:216
作者
Choi, Myunghwan [1 ,2 ,3 ]
Humar, Matjaz [1 ,2 ,4 ]
Kim, Seonghoon [1 ,2 ,5 ]
Yun, Seok-Hyun [1 ,2 ]
机构
[1] Harvard Univ, Sch Med, Cambridge, MA 02139 USA
[2] Massachusetts Gen Hosp, Wellman Ctr Photomed, Cambridge, MA 02139 USA
[3] Sungkyunkwan Univ, Global Biomed Engn, Ctr Neurosci & Imaging Res, Inst Basic Sci, Suwon, Gyeong Gi Do, South Korea
[4] Jozef Stefan Inst, Condensed Matter Dept, SI-1000 Ljubljana, Slovenia
[5] Korea Adv Inst Sci & Technol, Grad Sch Nanosci & Technol, Taejon 305701, South Korea
基金
美国国家卫生研究院;
关键词
biocompatible; hydrogels; implantable; optical fibers; sensing; WAVE-GUIDES; ENCAPSULATION;
D O I
10.1002/adma.201501603
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A biocompatible step-index optical fiber made of poly(ethylene glycol) and alginate hydrogels is demonstrated. The fabricated fiber exhibits excellent light-guiding efficiency in biological tissues. Moreover, the core of hydrogel fibers can be easily doped with functional molecules and nanoparticles for localized light emission, sensing, and therapy. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码:4081 / 4086
页数:6
相关论文
共 25 条
[11]   Optical properties of biological tissues: a review [J].
Jacques, Steven L. .
PHYSICS IN MEDICINE AND BIOLOGY, 2013, 58 (11) :R37-R61
[12]   Gel-based optical waveguides with live cell encapsulation and integrated microfluidics [J].
Jain, Aadhar ;
Yang, Allen H. J. ;
Erickson, David .
OPTICS LETTERS, 2012, 37 (09) :1472-1474
[13]   Thermosensitive sol-gel reversible hydrogels [J].
Jeong, B ;
Kim, SW ;
Bae, YH .
ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 (01) :37-51
[14]   Characterization and adaptive optical correction of aberrations during in vivo imaging in the mouse cortex [J].
Jia, Na ;
Sato, Takashi R. ;
Betzig, Eric .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (01) :22-27
[15]   Review of diverse optical fibers used in biomedical research and clinical practice [J].
Keiser, Gerd ;
Xiong, Fei ;
Cui, Ying ;
Shum, Perry Ping .
JOURNAL OF BIOMEDICAL OPTICS, 2014, 19 (08)
[16]   Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering: Part 1. Structure, gelation rate and mechanical properties [J].
Kuo, CK ;
Ma, PX .
BIOMATERIALS, 2001, 22 (06) :511-521
[17]   WHISPERING-GALLERY MODE MICRODISK LASERS [J].
MCCALL, SL ;
LEVI, AFJ ;
SLUSHER, RE ;
PEARTON, SJ ;
LOGAN, RA .
APPLIED PHYSICS LETTERS, 1992, 60 (03) :289-291
[18]   All-Biomaterial Laser Using Vitamin and Biopolymers [J].
Nizamoglu, Sedat ;
Gather, Malte C. ;
Yun, Seok Hyun .
ADVANCED MATERIALS, 2013, 25 (41) :5943-5947
[19]   Biocompatible Silk Printed Optical Waveguides [J].
Parker, Sara T. ;
Domachuk, Peter ;
Amsden, Jason ;
Bressner, Jason ;
Lewis, Jennifer A. ;
Kaplan, David L. ;
Omenetto, Fiorenzo G. .
ADVANCED MATERIALS, 2009, 21 (23) :2411-+
[20]   Rapid self-healing hydrogels [J].
Phadke, Ameya ;
Zhang, Chao ;
Arman, Bedri ;
Hsu, Cheng-Chih ;
Mashelkar, Raghunath A. ;
Lele, Ashish K. ;
Tauber, Michael J. ;
Arya, Gaurav ;
Varghese, Shyni .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (12) :4383-4388