Discovery of a novel orexigenic neuropeptide, 26RFa

被引：0
作者：
Chartrel, Nicolas [1 ]
Jeandel, Lydie [1 ]
Alexandre, David [1 ]
机构：
[1] Univ Rouen, INSERM, U982, IRIB, F-76821 Mont St Aignan, France
来源：
CORRESPONDANCES EN METABOLISMES HORMONES DIABETES ET NUTRITION | 2013年 / 17卷 / 03期
关键词：
Deorphanization; Neuropeptide; Hypothalamus; Feeding behaviour; Anorexia nervosa; HYPOTHALAMIC NEUROPEPTIDE; PEPTIDE; RECEPTOR; IDENTIFICATION; LIGAND; FAMILY; MICE;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
26RFa is a novel neuropeptide identified as the endogenous ligand of the human orphan receptor GPR103. 26RFa and GPR103 are localized in hypothalamic nuclei regulating feeding behaviour. 26RFa stimulates appetite. The 26RFa system is up-regulated in obese patients and adolescents suffering of anorexia nervosa.
引用
收藏
页码：66 / 69
页数：4
相关论文
共 16 条
[1]   Distribution of 26RFa binding sites and GPR103 mRNA in the central nervous system of the rat [J].
Bruzzone, Federica ;
Lectez, Benoit ;
Alexandre, David ;
Jegou, Sylvie ;
Mounien, Lourdes ;
Tollemer, Helene ;
Chatenet, David ;
Leprince, Jerome ;
Vallarino, Mauro ;
Vaudry, Hubert ;
Chartrel, Nicolas .
JOURNAL OF COMPARATIVE NEUROLOGY, 2007, 503 (04) :573-591
[2]   Anatomical distribution and biochemical characterization of the novel RFamide peptide 26RFa in the human hypothalamus and spinal cord [J].
Bruzzone, Federica ;
Lectez, Benoit ;
Tollemer, Helene ;
Leprince, Jerome ;
Dujardin, Cynthia ;
Rachidi, Walid ;
Chatenet, David ;
Baroncini, Marc ;
Beauvillain, Jean-Claude ;
Vallarino, Mauro ;
Vaudry, Hubert ;
Chartrel, Nicolas .
JOURNAL OF NEUROCHEMISTRY, 2006, 99 (02) :616-627
[3]   Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity [J].
Chartrel, N ;
Dujardin, C ;
Anouar, Y ;
Leprince, J ;
Decker, A ;
Clerens, S ;
Do-Régo, JC ;
Vandesande, F ;
Llorens-Cortes, C ;
Costentin, J ;
Beauvillain, JC ;
Vaudry, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (25) :15247-15252
[4]   The RFamide neuropeptide 26RFa and its role in the control of neuroendocrine functions [J].
Chartrel, Nicolas ;
Alonzeau, Jessy ;
Alexandre, David ;
Jeandel, Lydie ;
Alvear-Perez, Rodrigo ;
Leprince, Jerome ;
Boutin, Jean ;
Vaudry, Hubert ;
Anouar, Youssef ;
Llorens-Cortes, Catherine .
FRONTIERS IN NEUROENDOCRINOLOGY, 2011, 32 (04) :387-397
[5]   Behavioral effects of 26RFamide and related peptides [J].
do Rego, Jean-Claude ;
Leprince, Jerome ;
Chartrel, Nicolas ;
Vaudry, Hubert ;
Costentin, Jean .
PEPTIDES, 2006, 27 (11) :2715-2721
[6]   A new peptidic ligand and its receptor regulating adrenal function in rats [J].
Fukusumi, S ;
Yoshida, H ;
Fujii, R ;
Maruyama, M ;
Komatsu, H ;
Habata, Y ;
Shintani, Y ;
Hinuma, S ;
Fujino, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (47) :46387-46395
[7]   Orexigenic Neuropeptide 26RFa: New Evidence for an Adaptive Profile of Appetite Regulation in Anorexia Nervosa [J].
Galusca, Bogdan ;
Jeandel, Lydie ;
Germain, Natacha ;
Alexandre, David ;
Leprince, Jerome ;
Anouar, Youssef ;
Estour, Bruno ;
Chartrel, Nicolas .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2012, 97 (06) :2012-2018
[8]   Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155 [J].
Jiang, Y ;
Luo, L ;
Gustafson, EL ;
Yadav, D ;
Laverty, M ;
Murgolo, N ;
Vassileva, G ;
Zeng, M ;
Laz, TM ;
Behan, J ;
Qiu, P ;
Wang, LQ ;
Wang, SK ;
Bayae, M ;
Greene, J ;
Monsma, F ;
Zhang, FL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (30) :27652-27657
[9]   Ghrelin is a growth-hormone-releasing acylated peptide from stomach [J].
Kojima, M ;
Hosoda, H ;
Date, Y ;
Nakazato, M ;
Matsuo, H ;
Kangawa, K .
NATURE, 1999, 402 (6762) :656-660
[10]   The Orexigenic Activity of the Hypothalamic Neuropeptide 26RFa Is Mediated by the Neuropeptide Y and Proopiomelanocortin Neurons of the Arcuate Nucleus [J].
Lectez, Benoit ;
Jeandel, Lydie ;
El-Yamani, Fatima-Zohra ;
Arthaud, Sebastien ;
Alexandre, David ;
Mardargent, Aurelie ;
Jegou, Sylvie ;
Mounien, Lourdes ;
Bizet, Patrice ;
Magoul, Rabia ;
Anouar, Youssef ;
Chartrel, Nicolas .
ENDOCRINOLOGY, 2009, 150 (05) :2342-2350
12