Studies Toward the Synthesis of Caramboxin Analogues

被引：1

作者：

Oliveira Filho, Ronaldo E. ^{[1
]}

Higa, Vanessa M. ^{[1
]}

Omori, Alvaro T. ^{[1
]}

机构：

[1] Univ Fed ABC, Ctr Ciencias Nat & Humans, BR-09210580 Santo Andre, SP, Brazil

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2019年 / 30卷 / 03期

基金：

巴西圣保罗研究基金会;

关键词：

caramboxin; star fruit; Vilsmeier-Haack reaction; Lindgren oxidation; Curtius rearrangement; Bischler-Napieralski reaction; EFFICIENT SYNTHESIS; CARBOXYLIC-ACIDS; STAR FRUIT; OXIDATION; ALDEHYDES; CORE; RING;

D O I：

10.21577/0103-5053.20180202

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Intrigued by the recent discovery of caramboxin by Brazilian researchers, we present the results from our studies toward the racemic synthesis of caramboxin analogs through the ortho-carboxylation of 3,5-dimethoxy benzyl derivatives. Three different approaches were tested, and the route involving a Vilsmeier-Haack formylation followed by a Lindgren oxidation provide a potential intermediate for the synthesis of several caramboxin analogs.

引用

页码：528 / 540

页数：13

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