Elucidating the role of adipose tissue secreted factors in malignant transformation

被引：3

作者：

Chakraborty, Debrup ^{[1
]}

Benham, Vanessa ^{[1
]}

Bernard, Jamie J. ^{[1
]}

机构：

[1] Michigan State Univ, Dept Pharmacol & Toxicol, E Lansing, MI 48824 USA

来源：

ADIPOCYTE | 2018年 / 7卷 / 01期

基金：

美国国家卫生研究院;

关键词：

obesity; cancer; FGF2; adiposity; visceral fat; skin cancer; breast cancer; VISCERAL FAT ACCUMULATION; FIBROBLAST-GROWTH-FACTOR; RISK-FACTOR; ABDOMINAL OBESITY; CANCER; LEPTIN; FGF2; CARCINOGENESIS; PROLIFERATION; HYPERTENSION;

D O I：

10.1080/21623945.2017.1388971

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although there is a growing number of incidences of obesity and obesity-linked cancers, how excess adiposity actually causes cancer has not been fully explained. Our previous study showed that removal of visceral adipose tissue significantly reduced the number of ultraviolet radiation (UVR)-initiated, high-fat diet-promoted skin cancers. This commentary focuses on our recently published study (Chakraborty, etal., 2017) which demonstrated that fibroblast growth factor-2 (FGF2) released from visceral adipose tissue is a key factor in the malignant transformation of epithelial cells. Within this commentary we have provided additional interpretations and new data in support of the role of FGF2 in adiposity-associated tumorigenesis.

引用

页码：45 / 48

页数：4

共 28 条

[1] Relationship of generalized and regional adiposity to insulin sensitivity in men with NIDDM [J].

Abate, N ;

Garg, A ;

Peshock, RM ;

StrayGundersen, J ;

AdamsHuet, B ;

Grundy, SM .

DIABETES, 1996, 45 (12) :1684-1693

[2]

Amjadi Fatemehsadat, 2016, Adv Biomed Res, V5, P127, DOI 10.4103/2277-9175.187005

[3] Leptin induces mitogenic effect on human choriocarcinoma cell line (JAr) via MAP kinase activation in a glucose-dependent fashion [J].

Bifulco, G ;

Trencia, A ;

Caruso, M ;

Tommaselli, GA ;

Miele, C ;

Di Carlo, C ;

Beguinot, F ;

Nappi, C .

PLACENTA, 2003, 24 (04) :385-391

[4] Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults [J].

Calle, EE ;

Rodriguez, C ;

Walker-Thurmond, K ;

Thun, MJ .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (17) :1625-1638

[5] Obesity as a risk factor for development and poor prognosis of breast cancer [J].

Carmichael, A. R. .

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2006, 113 (10) :1160-1166

[6] Fibroblast growth factor receptor is a mechanistic link between visceral adiposity and cancer [J].

Chakraborty, D. ;

Benham, V. ;

Bullard, B. ;

Kearney, T. ;

Hsia, H. C. ;

Gibbon, D. ;

Demireva, E. Y. ;

Lunt, S. Y. ;

Bernard, J. J. .

ONCOGENE, 2017, 36 (48) :6668-6679

[7] Applying What We Know to Accelerate Cancer Prevention [J].

Colditz, Graham A. ;

Wolin, Kathleen Y. ;

Gehlert, Sarah .

SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (127)

[8] Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion [J].

Coleman, Stacey J. ;

Chioni, Athina-Myrto ;

Ghallab, Mohammed ;

Anderson, Rhys K. ;

Lemoine, Nicholas R. ;

Kocher, Hemant M. ;

Grose, Richard P. .

EMBO MOLECULAR MEDICINE, 2014, 6 (04) :467-481

[9]

Despres Jean-Pierre, 2007, Crit Pathw Cardiol, V6, P51, DOI 10.1097/HPC.0b013e318057d4c9

[10] Associations of Plasma FGF2 Levels and Polymorphisms in the FGF2 Gene with Obesity Phenotypes in Han Chinese Population [J].

Hao, Ruo-Han ;

Guo, Yan ;

Dong, Shan-Shan ;

Weng, Gai-Zhi ;

Yan, Han ;

Zhu, Dong-Li ;

Chen, Xiao-Feng ;

Chen, Jia-Bin ;

Yang, Tie-Lin .

SCIENTIFIC REPORTS, 2016, 6

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