Inflammatory Markers and Risk of Epithelial Ovarian Cancer by Tumor Subtypes: The EPIC Cohort

被引：48

作者：

Ose, Jennifer ^{[1
]}

Schock, Helena ^{[1
]}

Tjonneland, Anne ^{[2
]}

Hansen, Louise ^{[2
]}

Overvad, Kim ^{[3
]}

Dossus, Laure ^{[4
,5
,6
]}

Clavel-Chapelon, Francoise ^{[4
,5
,6
]}

Baglietto, Laura ^{[7
,8
]}

Boeing, Heiner ^{[9
]}

Trichopolou, Antonia ^{[10
,11
,12
]}

Benetou, Vassiliki ^{[10
,11
]}

Lagiou, Pagona ^{[11
,12
,13
]}

Masala, Giovanna ^{[14
]}

Tagliabue, Giovanna ^{[15
]}

Tumino, Rosario ^{[16
]}

Sacerdote, Carlotta ^{[17
,18
]}

Mattiello, Amalia ^{[19
]}

Bueno-de-Mesquita, H. B ^{[20
,21
,22
,23
]}

Peeters, Petra H. M. ^{[24
]}

Onland-Moret, N. Charlotte ^{[25
]}

Weiderpass, Elisabete ^{[26
,27
,28
,29
]}

Gram, Inger T. ^{[26
]}

Sanchez, Soledad ^{[30
]}

Obon-Santacana, Mireia ^{[31
]}

Sanchez-Perez, Maria-Jose ^{[32
,33
]}

Larranaga, Nerea ^{[32
,34
]}

Huerta Castano, Jose Mara ^{[32
,35
]}

Ardanaz, Eva ^{[32
,36
]}

Brandstedt, Jenny ^{[37
,38
]}

Lundin, Eva ^{[39
]}

Idahl, Annika ^{[40
,41
]}

Travis, Ruth C. ^{[42
]}

Khaw, Kay-Tee ^{[43
]}

Rinaldi, Sabina ^{[44
]}

Romieu, Isabelle ^{[44
]}

Merritt, Melissa A. ^{[45
]}

Gunter, Marc J. ^{[45
]}

Riboli, Elio ^{[45
]}

Kaaks, Rudolf ^{[1
]}

Fortner, Renee T. ^{[1
]}

机构：

[1] German Canc Res Ctr, Div Canc Epidemiol, D-69120 Heidelberg, Germany

[2] Danish Canc Soc, Res Ctr, Copenhagen, Denmark

[3] Aarhus Univ, Sect Epidemiol Danish Canc, Dept Publ Hlth, Aarhus, Denmark

[4] INSERM, Ctr Res Epidemiol & Populat Hlth CESP, Nutr Hormones & Womens Hlth Team, Villejuif, France

[5] Univ Paris 11, UMRS 1018, Villejuif, France

[6] IGR, Villejuif, France

[7] Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia

[8] Univ Melbourne, Sch Populat & Global Hlth, Ctr Biostat & Epidemiol, Melbourne, Vic 3010, Australia

[9] German Inst Human Nutr DIfE Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[10] Hellen Hlth Fdn, Athens, Greece

[11] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[12] Acad Athens, Bur Epidemiol Res, Athens, Greece

[13] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[14] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[15] Fdn IRCCS Ist Nazl Tumori, Lombardy Canc Registry Unit, Milan, Italy

[16] ASP Ragusa, Civ MP Arezzo Hosp, Canc Registry & Histopathol Unit, Milan, Italy

[17] Ctr Canc Prevent CPOPiemonte, Turin, Italy

[18] Human Genet Fdn, Turin, Italy

[19] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[20] Natl Inst Publ Hlth & Environm RIVM, Dept Determinants Chron Dis DCD, Bilthoven, Netherlands

[21] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[22] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Biostat, London, England

[23] Univ Malaya, Fac Med, Dept Social & Prevent Med, Kuala Lumpur, Malaysia

[24] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands

[25] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[26] Univ Tromso, Dept Community Med, Fac Hlth Sci, Arctic Univ Norway, Tromso, Norway

[27] Canc Registry Norway, Oslo, Norway

[28] Karolinska Inst, Dept Epidemiol & Biostat, Stockholm, Sweden

[29] Folkhalsan Res Ctr, Dept Genet Epidemiol, Helsinki, Finland

[30] Publ Hlth Directorate, Asturias, Spain

[31] Catalan Inst Oncol ICO IDIBELL, Canc Epidemiol Res Program, Unit Nutr Environm & Canc, Barcelona, Spain

[32] CIBER Epidemiol & Salud Publ, Madrid, Spain

[33] Univ Granada, Hosp Univ Granada, Inst Invest Biosanitaria ibs GRANADA, Andalusian Sch Publ Hlth, Granada, Spain

[34] Basque Reg Hlth Dept, Publ Hlth Div Gipuzkoa BIODONOSTIA, Murcia, Spain

[35] Murcia Reg Hlth Author, Dept Epidemiol, Murcia, Spain

[36] Navarre Publ Hlth Inst, Pamplona, Spain

[37] Skane Univ Hosp, Dept Surg, Malmo, Sweden

[38] Lund Univ, Skane Univ Hosp, Div Oncol & Pathol, Dept Clin Sci, Lund, Sweden

[39] Umea Univ, Dept Med Biosci Pathol, Umea, Sweden

[40] Umea Univ, Dept Clin Sci Obstet & Gynecol, Umea, Sweden

[41] Umea Univ, Dept Publ Hlth & Clin Med, Nutr Res, Umea, Sweden

[42] Univ Oxford, Canc Epidemiol Unit, Oxford, England

[43] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England

[44] Int Agcy Res Canc, Biomarkers Grp, F-69372 Lyon, France

[45] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2015年 / 24卷 / 06期

基金：

英国医学研究理事会;

关键词：

C-REACTIVE PROTEIN; FALLOPIAN-TUBE; BREAST-CANCER; ANTHROPOMETRIC MEASURES; PHYSICAL-ACTIVITY; CENTRAL ADIPOSITY; BODY-SIZE; OBESITY; SERUM; INTERLEUKIN-6;

D O I：

10.1158/1055-9965.EPI-14-1279-T

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Evidence suggests an etiologic role for inflammation in ovarian carcinogenesis and heterogeneity between tumor subtypes and anthropometric indices. Prospective studies on circulating inflammatory markers and epithelial invasive ovarian cancer (EOC) have predominantly investigated overall risk; data characterizing risk by tumor characteristics (histology, grade, stage, dualistic model of ovarian carcinogenesis) and anthropometric indices are sparse. Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate C-reactive protein (CRP), IL6, and EOC risk by tumor characteristics. A total of 754 eligible EOC cases were identified; two controls (n = 1,497) were matched per case. We used multivariable conditional logistic regression to assess associations. Results: CRP and IL6 were not associated with overall EOC risk. However, consistent with prior research, CRP >10 versus CRP <= 1 mg/L was associated with higher overall EOC risk [OR, 1.67 (1.03-2.70)]. We did not observe significant associations or heterogeneity in analyses by tumor characteristics. In analyses stratified by waist circumference, inflammatory markers were associated with higher risk among women with higher waist circumference; no association was observed for women with normal waist circumference [e.g., IL6: waist <= 80: ORlog2, 0.97 (0.81-1.16); waist >88: ORlog2, 1.78 (1.28-2.48), P-heterogeneity <= 0.01]. Conclusions: Our data suggest that high CRP is associated with increased risk of overall EOC, and that IL6 and CRP may be associated with EOC risk among women with higher adiposity. Impact: Our data add to global evidence that ovarian carcinogenesis may be promoted by an inflammatory milieu. (C)2015 AACR.

引用

页码：951 / 961

页数：11

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