High-Grade Neuroendocrine Carcinoma with Bronchial Intraepithelial Tumor Spread Possibly a New Histologic Feature of Large-Cell Neuroendocrine Carcinoma

被引：6

作者：

Kojima, Hideaki ^{[1
]}

Watanabe, Reiko ^{[2
]}

Isaka, Mitsuhiro ^{[1
]}

Shimizu, Reiko ^{[1
]}

Kayata, Hiroyuki ^{[1
]}

Miyata, Naoko ^{[1
]}

Maniwa, Tomohiro ^{[1
]}

Takahashi, Shoji ^{[1
]}

Ito, Ichiro ^{[2
]}

Kameya, Toru ^{[2
]}

Funai, Kazuhito ^{[3
]}

Ohde, Yasuhisa ^{[1
]}

Nakajima, Takashi ^{[2
]}

机构：

[1] Shizuoka Canc Ctr, Div Thorac Surg, Nagaizumi, Shizuoka, Japan

[2] Shizuoka Canc Ctr, Div Pathol, Nagaizumi, Shizuoka, Japan

[3] Hamamatsu Univ Sch Med, Dept Surg 1, Hamamatsu, Shizuoka 4313192, Japan

来源：

JOURNAL OF THORACIC ONCOLOGY | 2015年 / 10卷 / 09期

关键词：

High-grade neuroendocrine carcinoma; Large-cell neuroendocrine carcinoma; Bronchial intraepithelial tumor spread; Bronchus; LUNG-CARCINOMA;

D O I：

10.1097/JTO.0000000000000616

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: During surgical resection of a peripherally located high-grade neuroendocrine carcinoma (HGNEC), we unexpectedly discovered prominent bronchial intraepithelial tumor spread up to the surgical end of the bronchus. Because bronchial intraepithelial tumor spread of peripherally located HGNEC has been rarely reported, we conducted a retrospective analysis at our hospital. Methods: We histologically reviewed surgically resected HGNEC cases to assess bronchial intraepithelial spread of tumor cells. HGNECs with bronchial intraepithelial tumor spread were further studied by immunohistochemistry for neuroendocrine markers, and their clinicopathological characteristics were evaluated. Results: Of 1778 cases of surgically resected lung cancer in our hospital, 47 cases of HGNEC were evaluated. Bronchial intraepithelial tumor spread was observed in nine cases (19.1%); eight of these cases were large-cell neuroendocrine carcinoma (LCNEC) or small-cell lung carcinoma with an LCNEC component. Moreover, bronchial intraepithelial tumor spread was continuous from the primary tumor to the resected end of the bronchus in four cases, and all these cases had an LCNEC component. Furthermore, HGNEC with bronchial intraepithelial tumor spread was associated with a higher recurrence rate than no bronchial intraepithelial tumor spread. Conclusion: The results of this study suggest that bronchial intraepithelial tumor spread is commonly observed in cases of peripherally located HGNEC and may be a unique form of tumor invasion, especially tumors with LCNEC morphology. Therefore, surgeons and pathologists should be cognizant of bronchial intraepithelial tumor spread in peripherally located HGNEC, as well as its potential role as an indicator of HGNEC aggressiveness.

引用

页码：1337 / 1340

页数：4