Treatment of Helicobacter pylori infection 2012

被引：32
作者：
Tepes, Bojan [2 ]
O'Connor, Anthony [1 ]
Gisbert, Javier P. [3 ]
O'Morain, Colm [1 ]
机构：
[1] Trinity Coll Dublin, Adelaide & Meath Hosp Natl Childrens Hosp, Dept Gastroenterol, Dublin 24, Ireland
[2] Med Ctr Rogaska, Dept Gastroenterol, Rogashka Slatina, Slovenia
[3] CIBEREHD, Inst Invest Sanitaria Princesa IP, Hosp Univ Princesa, Gastroenterol Unit, Madrid, Spain
来源：
HELICOBACTER | 2012年 / 17卷
关键词：
First-line therapy; second-line therapy; rescue therapy; resistance; susceptibility testing; compliance; 10-DAY SEQUENTIAL THERAPY; RANDOMIZED CLINICAL-TRIAL; STANDARD TRIPLE THERAPY; CONTAINING QUADRUPLE THERAPY; TREATMENT-NAIVE PATIENTS; DRUG-RESISTANT STRAINS; ERADICATION THERAPY; ANTIBIOTIC-RESISTANCE; CONCOMITANT THERAPY; CLARITHROMYCIN;
D O I：
10.1111/j.1523-5378.2012.00981.x
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Helicobacter pylori resistance rates to antibiotics vary in different countries and even in different regions of the same country. Choice of treatment is strongly dependent on antibiotic resistance rates. In some countries, triple therapy with a proton-pump inhibitor, amoxicillin, and clarithromycin is still the best option, but eradication results fall short of what would be desired (9095%) in countries with clarithromycin resistance >20%, bismuth-containing quadruple therapy, or nonbismuth sequential or concomitant therapies may then be the preferred option. Newer antibiotic regimens are awaited. Vaccination would be the best option, especially for developing countries, but little progress has been made in designing a vaccine.
引用
收藏
页码：36 / 42
页数：7
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