Anthraquinones from a Marine-Derived Streptomyces spinoverrucosus

被引：29
|
作者：
Hu, Youcai [1 ]
Martinez, Elisabeth D. [2 ]
MacMillan, John B. [1 ]
机构：
[1] Univ Texas SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA
[2] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 10期
关键词：
IDENTIFICATION;
D O I：
10.1021/np3004326
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Four new anthraquinone analogues including galvaquinones A-C (1-3) and an isolation artifact, 5,8-dihydroxy-2,2,4-trimethyl-6-(3-methylbutyl)-anthra[9,1-de][1,3]oxazin-7(2H)-one (4), were isolated from a marine-derived Streptomyces spinoverrucosus based on activity in an image-based assay to identify epigenetic modifying compounds. The structures of 1-4 were elucidated by comprehensive NMR and MS spectroscopic analysis. Galvaquinone B (2) was found to show epigenetic modulatory activity at 1.0 mu M and exhibited moderate cytotoxicity against non-small-cell lung cancer (NSCLC) cell lines Calu-3 and H2887.
引用
收藏
页码：1759 / 1764
页数：6
相关论文
共 50 条
  • [21] Cytotoxic and Antimicrobial Napyradiomycins from Two Marine-Derived Streptomyces Strains
    Cheng, Yuan-Bin
    Jensen, Paul R.
    Fenical, William
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2013, 2013 (18) : 3751 - 3757
  • [22] Piperazimycins:: Cytotoxic hexadepsipeptides from a marine-derived bacterium of the genus Streptomyces
    Miller, Eric D.
    Kauffman, Christopher A.
    Jensen, Paul R.
    Fenical, William
    JOURNAL OF ORGANIC CHEMISTRY, 2007, 72 (02): : 323 - 330
  • [23] Two butenolides with PPARα agonistic activity from a marine-derived Streptomyces
    Yasuhiro Igarashi
    Marumi Ikeda
    Satoshi Miyanaga
    Hiroaki Kasai
    Yoshikazu Shizuri
    Nobuyasu Matsuura
    The Journal of Antibiotics, 2015, 68 : 345 - 347
  • [24] Identification, Bioactivity, and Productivity of Actinomycins from the Marine-Derived Streptomyces heliomycini
    Wang, Dongyang
    Wang, Cong
    Gui, Pengyan
    Liu, Haishan
    Khalaf, Sameh M. H.
    Elsayed, Elsayed A.
    Wadaan, Mohammed A. M.
    Hozzein, Wael N.
    Zhu, Weiming
    FRONTIERS IN MICROBIOLOGY, 2017, 8
  • [25] Chromomycin SA analogs from a marine-derived Streptomyces sp.
    Hu, Youcai
    Espindola, Ana Paula D. M.
    Stewart, Nathan A.
    Wei, Shuguang
    Posner, Bruce A.
    MacMillan, John B.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19 (17) : 5183 - 5189
  • [26] Two Antimycin A Analogues from Marine-Derived Actinomycete Streptomyces lusitanus
    Han, Zhuang
    Xu, Ying
    McConnell, Oliver
    Liu, Lingli
    Li, Yongxin
    Qi, Shuhua
    Huang, Xiangzhong
    Qian, Peiyuan
    MARINE DRUGS, 2012, 10 (03): : 668 - 676
  • [27] Two new compounds from a marine-derived Streptomyces sp.
    Zhou, Si-Yu
    Zou, Yan-Lin
    Wang, Guo-Wei
    Liao, Zhi-Hua
    Chen, Min
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2017, 19 (12) : 1172 - 1176
  • [28] A New Antimycin Analog from Marine-Derived Streptomyces sp.
    Shaikh, A.
    Mullowney, M.
    O'hainmhire, E.
    Colunga-Hernandez, D.
    Burdette, J.
    Murphy, B. T.
    PLANTA MEDICA, 2013, 79 (10) : 843 - 843
  • [29] Two butenolides with PPARα agonistic activity from a marine-derived Streptomyces
    Igarashi, Yasuhiro
    Ikeda, Marumi
    Miyanaga, Satoshi
    Kasai, Hiroaki
    Shizuri, Yoshikazu
    Matsuura, Nobuyasu
    JOURNAL OF ANTIBIOTICS, 2015, 68 (05): : 345 - 347
  • [30] Angucycline and angucyclinone derivatives from the marine-derived Streptomyces sp.
    Liu, Ming
    Yang, Ying-Jie
    Gong, Ge
    Li, Zhi
    Zhang, Lu
    Guo, Lin
    Xu, Bo
    Zhang, Shu-Min
    Xie, Ze-Ping
    CHIRALITY, 2022, 34 (02) : 421 - 427
12345