Anthraquinones from a Marine-Derived Streptomyces spinoverrucosus

被引：29

作者：

Hu, Youcai ^{[1
]}

Martinez, Elisabeth D. ^{[2
]}

MacMillan, John B. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 10期

关键词：

IDENTIFICATION;

D O I：

10.1021/np3004326

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new anthraquinone analogues including galvaquinones A-C (1-3) and an isolation artifact, 5,8-dihydroxy-2,2,4-trimethyl-6-(3-methylbutyl)-anthra[9,1-de][1,3]oxazin-7(2H)-one (4), were isolated from a marine-derived Streptomyces spinoverrucosus based on activity in an image-based assay to identify epigenetic modifying compounds. The structures of 1-4 were elucidated by comprehensive NMR and MS spectroscopic analysis. Galvaquinone B (2) was found to show epigenetic modulatory activity at 1.0 mu M and exhibited moderate cytotoxicity against non-small-cell lung cancer (NSCLC) cell lines Calu-3 and H2887.

引用

页码：1759 / 1764

页数：6

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