Anthraquinones from a Marine-Derived Streptomyces spinoverrucosus

被引：29

作者：

Hu, Youcai ^{[1
]}

Martinez, Elisabeth D. ^{[2
]}

MacMillan, John B. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 10期

关键词：

IDENTIFICATION;

D O I：

10.1021/np3004326

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new anthraquinone analogues including galvaquinones A-C (1-3) and an isolation artifact, 5,8-dihydroxy-2,2,4-trimethyl-6-(3-methylbutyl)-anthra[9,1-de][1,3]oxazin-7(2H)-one (4), were isolated from a marine-derived Streptomyces spinoverrucosus based on activity in an image-based assay to identify epigenetic modifying compounds. The structures of 1-4 were elucidated by comprehensive NMR and MS spectroscopic analysis. Galvaquinone B (2) was found to show epigenetic modulatory activity at 1.0 mu M and exhibited moderate cytotoxicity against non-small-cell lung cancer (NSCLC) cell lines Calu-3 and H2887.

引用

页码：1759 / 1764

页数：6

共 32 条

[1] Mansoquinone: Isolation and structure elucidation of new antibacterial aromatic polyketides from terrestrial Streptomyces Sp Eg5 [J].

Abdelfattah, Mohamed S. .

NATURAL PRODUCT RESEARCH, 2009, 23 (03) :212-218

[2] Identification of Four Potential Epigenetic Modulators from the NCI Structural Diversity Library Using a Cell-Based Assay [J].

Best, Anne M. ;

Chang, Jianjun ;

Dull, Angie B. ;

Beutler, John A. ;

Martinez, Elisabeth D. .

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2011,

[3] Identification of Novel Compounds That Increase SMN Protein Levels Using an Improved SMN2 Reporter Cell Assay [J].

Cherry, Jonathan J. ;

Evans, Matthew C. ;

Ni, Jake ;

Cuny, Gregory D. ;

Glicksman, Marcie A. ;

Androphy, Elliot J. .

JOURNAL OF BIOMOLECULAR SCREENING, 2012, 17 (04) :481-495

[4]

Crawford J. M., 2011, J CHEM SOC CHEM COMM, V47, P7559, DOI DOI 10.1039/C1CC11574J

[5] POLYCYCLIC HYDROXYQUINONES .27. TAUTOMERISM IN 1,4-DIHYDROXY-9,10-ANTHRAQUINONE MONOIMINES - CYCLOADDITION REACTIONS OF THEIR 1,4-ANTHRAQUINONOID TAUTOMERS [J].

FARINA, F ;

MOLINA, MT ;

NOHEDA, P ;

PAREDES, MC .

TETRAHEDRON, 1992, 48 (39) :8437-8450

[6] Developing a new resource for drug discovery: marine actinomycete bacteria [J].

Fenical, William ;

Jensen, Paul R. .

NATURE CHEMICAL BIOLOGY, 2006, 2 (12) :666-673

[7] Epigenetic Therapy: Histone Acetylation, DNA Methylation and Anti-Cancer Drug Discovery [J].

Ganesan, A. ;

Nolan, L. ;

Crabb, S. J. ;

Packham, G. .

CURRENT CANCER DRUG TARGETS, 2009, 9 (08) :963-981

[8]

George S. M., 2010, NAT BIOTECHNOL, V28, P1259

[9] DNA methyltransferases as targets for cancer therapy [J].

Ghoshal, Kalpana ;

Bai, Shoumei .

DRUGS OF TODAY, 2007, 43 (06) :395-422

[10] Vorinostat [J].

Grant, Steven ;

Easley, Chris ;

Kirkpatrick, Peter .

NATURE REVIEWS DRUG DISCOVERY, 2007, 6 (01) :21-22

← 1 2 3 4 →