Anthraquinones from a Marine-Derived Streptomyces spinoverrucosus

被引：29
|
作者：
Hu, Youcai [1 ]
Martinez, Elisabeth D. [2 ]
MacMillan, John B. [1 ]
机构：
[1] Univ Texas SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA
[2] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 10期
关键词：
IDENTIFICATION;
D O I：
10.1021/np3004326
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Four new anthraquinone analogues including galvaquinones A-C (1-3) and an isolation artifact, 5,8-dihydroxy-2,2,4-trimethyl-6-(3-methylbutyl)-anthra[9,1-de][1,3]oxazin-7(2H)-one (4), were isolated from a marine-derived Streptomyces spinoverrucosus based on activity in an image-based assay to identify epigenetic modifying compounds. The structures of 1-4 were elucidated by comprehensive NMR and MS spectroscopic analysis. Galvaquinone B (2) was found to show epigenetic modulatory activity at 1.0 mu M and exhibited moderate cytotoxicity against non-small-cell lung cancer (NSCLC) cell lines Calu-3 and H2887.
引用
收藏
页码：1759 / 1764
页数：6
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