Fabrication of Electrospun Antimicrobial Nanofibers Containing Metronidazole Using Nanospider Technology

被引：43

作者：

El-Newehy, Mohamed H. ^{[1
,2
]}

Al-Deyab, Salem S. ^{[1
]}

Kenawy, El-Refaie ^{[2
]}

Abdel-Megeed, Ahmed ^{[3
,4
]}

机构：

[1] King Saud Univ, Coll Sci, Dept Chem, Petrochem Res Chair, Riyadh 11451, Saudi Arabia

[2] Tanta Univ, Fac Sci, Dept Chem, Tanta 31527, Egypt

[3] King Saud Univ, Coll Sci, Dept Bot & Microbiol, Riyadh 11451, Saudi Arabia

[4] Univ Alexandria, Fac Agr Saba Basha, Dept Plant Protect, Alexandria 2153, Egypt

来源：

FIBERS AND POLYMERS | 2012年 / 13卷 / 06期

关键词：

Nanospider; Electrospinning; Poly(vinyl alcohol); Controlled-release; Antimicrobial activity; Poly(ethylene oxide); CONTROLLED-RELEASE; MATS;

D O I：

10.1007/s12221-012-0709-4

中图分类号：

TB3 [工程材料学]; TS1 [纺织工业、染整工业];

学科分类号：

0805 ; 080502 ; 0821 ;

摘要：

Nanospider technology as a modified electrospinning technique was used for the fabrication of electrospun nanofibers based on poly(vinyl alcohol) (PVA)/poly(ethylene oxide) (PEO) blend as drug delivery system (DDS) for metronidazole (MTZ) as an antimicrobial drug. Electrospun PVA/PEO/MTZ composite nanofibers were stabilized against disintegration in water by heating in oven at 110 degrees C, or by soaking in isopropyl alcohol for 6 hrs. Incorporation of MTZ into electrospun nanofibers was confirmed by SEM, FT-IR spectra and TGA. The drug release results showed that the burst release was suppressed with stabilized electrospun nanofibers compared with non-stabilized ones. Electrospun PVA/PEO/MTZ composite nanofibers exhibited remarkable antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Aspergillus niger, Penicillium notation and Aspergillus flavus which varies with the species of the tested organisms.

引用

页码：709 / 717

页数：9

共 31 条

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