Copper(I) catalyzed asymmetric 1,2-addition of Grignard reagents to α-methyl substituted α,β-unsaturated ketones

被引：52

作者：

Madduri, Ashoka V. R. ^{[1
]}

Minnaard, Adriaan J. ^{[1
]}

Harutyunyan, Syuzanna R. ^{[1
]}

机构：

[1] Univ Groningen, Stratingh Inst Chem, NL-9747 AG Groningen, Netherlands

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 10期

关键词：

TERTIARY ALCOHOLS; ENANTIOSELECTIVE ALKENYLATION; CONJUGATE ADDITION; ALKYLATION; ALDEHYDES; DIALKYLZINC; ARYLATION;

D O I：

10.1039/c1cc16725a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first catalytic enantioselective 1,2-addition of Grignard reagents to ketones is presented. This additive-free copper(I) catalyzed 1,2-addition provides chiral allylic tertiary alcohols with an er of up to 98 : 2 and excellent yields due to the complete shift of overwhelming 1,4-selectivity of copper(I)-catalysts towards 1,2-selectivity in the addition reaction to enones.

引用

页码：1478 / 1480

页数：3

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