Continuous-Flow Suzuki-Miyaura and Mizoroki-Heck Reactions under Microwave Heating Conditions

被引：30
|
作者：
Monguchi, Yasunari [1 ,2 ]
Ichikawa, Tomohiro [1 ]
Yamada, Tsuyoshi [1 ]
Sawama, Yoshinari [1 ]
Sajiki, Hironao [1 ]
机构：
[1] Gifu Pharmaceut Univ, Organ Chem Lab, 1-25-4 Daigaku Nishi, Gifu 5011196, Japan
[2] Daiichi Univ Pharm, Organ Chem Lab, Minami Ku, 22-1 Tamagawa Cho, Fukuoka, Fukuoka 8158511, Japan
来源：
CHEMICAL RECORD | 2019年 / 19卷 / 01期
关键词：
Cross-coupling; Flow reaction; Heterogeneous catalysis; Homogeneous catalysis; Microwave chemistry; HETEROGENEOUS PALLADIUM CATALYST; CROSS-COUPLING REACTIONS; POLYUREA-ENCAPSULATED PALLADIUM; SUPPORTED PD CATALYSTS; HIGHLY-ACTIVE CATALYST; LIGAND-FREE; MESOPOROUS SILICA; ARYL HALIDES; ORGANIC-SYNTHESIS; MICROENCAPSULATED PALLADIUM;
D O I：
10.1002/tcr.201800063
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Microwave-assisted continuous-flow reactions have attracted significant interest from synthetic organic chemists, especially process chemists from practical points of view, due to a less complicated shift to large-scale synthesis based on simple and continuous access to products with low energy requirements. In this personal account, we focused on the Suzuki-Miyaura and Mizoroki-Heck reactions, both of which are significantly important cross-coupling reactions for the synthesis of various functional materials. Microwave power is effective for heating. Typical homogeneous palladium catalysts, such as PdCl2(PPh3)(2), Pd(PPh3)(4), and Pd(OAc)(2), as well as heterogeneous palladium catalysts, such as Pd-film, Pd/Al2O3, Pd/SiO2, and Pd supported on polymers, can be used for these reactions.
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页码：3 / 14
页数：12
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