Direct Peptide Lipidation through Thiol-Ene Coupling Enables Rapid Synthesis and Evaluation of Self-Adjuvanting Vaccine Candidates

被引：50

作者：

Wright, Tom H. ^{[1
]}

Brooks, Anna E. S. ^{[2
,3
]}

Didsbury, Alicia J. ^{[2
,3
]}

Williams, Geoffrey M. ^{[1
]}

Harris, Paul W. R. ^{[1
,2
]}

Dunbar, P. Rod ^{[2
,3
]}

Brimble, Margaret A. ^{[1
,2
,3
]}

机构：

[1] Univ Auckland, Sch Chem Sci, Auckland Cent 1142, New Zealand

[2] Univ Auckland, Maurice Wilkins Ctr Mol Biodiscovery, Auckland Cent 1142, New Zealand

[3] Univ Auckland, Sch Biol Sci, Auckland Cent 1142, New Zealand

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 40期

关键词：

adjuvants; immunology; peptides; thiol-ene reaction; vaccines; INNATE IMMUNITY;

D O I：

10.1002/anie.201305620

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A radical lipidation: Application of a novel thiol-ene lipidation enables the one-step synthesis of self-adjuvanting antigenic peptides as vaccine candidates. The resultant monoacyl lipopeptides are shown to activate monocytes in a robust manner. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：10616 / 10619

页数：4

共 23 条

[21] Synthesis of Carbohydrate-Functionalised Sequence-Defined Oligo(amidoamine)s by Photochemical ThiolEne Coupling in a Continuous Flow Reactor
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[23] A Modular Approach to Assembly of Totally Synthetic Self-adjuvanting Lipopeptide-based Vaccines Allows Conformational Epitope Building
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