Direct Peptide Lipidation through Thiol-Ene Coupling Enables Rapid Synthesis and Evaluation of Self-Adjuvanting Vaccine Candidates

被引：50
作者：
Wright, Tom H. [1 ]
Brooks, Anna E. S. [2 ,3 ]
Didsbury, Alicia J. [2 ,3 ]
Williams, Geoffrey M. [1 ]
Harris, Paul W. R. [1 ,2 ]
Dunbar, P. Rod [2 ,3 ]
Brimble, Margaret A. [1 ,2 ,3 ]
机构：
[1] Univ Auckland, Sch Chem Sci, Auckland Cent 1142, New Zealand
[2] Univ Auckland, Maurice Wilkins Ctr Mol Biodiscovery, Auckland Cent 1142, New Zealand
[3] Univ Auckland, Sch Biol Sci, Auckland Cent 1142, New Zealand
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 40期
关键词：
adjuvants; immunology; peptides; thiol-ene reaction; vaccines; INNATE IMMUNITY;
D O I：
10.1002/anie.201305620
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A radical lipidation: Application of a novel thiol-ene lipidation enables the one-step synthesis of self-adjuvanting antigenic peptides as vaccine candidates. The resultant monoacyl lipopeptides are shown to activate monocytes in a robust manner. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：10616 / 10619
页数：4
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