Kidney Regeneration and Stem Cells

被引：5

作者：

Takaori, Koji ^{[1
]}

Yanagita, Motoko ^{[1
]}

机构：

[1] Kyoto Univ, Dept Nephrol, Grad Sch Med, Kyoto, Japan

来源：

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY | 2014年 / 297卷 / 01期

关键词：

acute kidney injury; tubular regeneration; renal stem cells; progenitor cell; lineage tracing; regenerative medicine; mesenchymal stem cells; ACUTE-RENAL-FAILURE; MARROW STROMAL CELLS; EPITHELIAL-CELLS; ADULT KIDNEY; POPULATION CELLS; PROGENITOR CELLS; PROXIMAL TUBULE; REPAIR; PROLIFERATION; IDENTIFICATION;

D O I：

10.1002/ar.22801

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The kidney has the capacity to recover from ischemic and toxic insults. Although there has been debate about the origin of cells that replace injured epithelial cells, it is now widely recognized that intrinsic surviving tubular cells are responsible for the repair. On the other hand, the cells, which have stem cell-like characteristics, have been isolated in the kidney using various methods, but it remains unknown if these stem cells actually exist in the adult kidney and if they are involved in kidney regeneration. This review will focus on the pathophysiology of kidney regeneration and the contribution of renal stem cells. We also discuss possible therapeutic applications to kidney disease. Anat Rec, 297:129-136. 2014. (c) 2013 Wiley Periodicals, Inc.

引用

页码：129 / 136

页数：8

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