RETRACTED: Volasertib suppresses the growth of human hepatocellular carcinoma in vitro and in vivo (Retracted Article)

被引:0
|
作者
Zheng, Di-Wei [1 ,2 ]
Xue, You-Qiu [1 ,2 ,3 ]
Li, Yong [4 ]
Di, Jin-Ming [5 ]
Qiu, Jian-Ge [1 ,2 ]
Zhang, Wen-Ji [1 ,2 ]
Jiang, Qi-Wei [1 ,2 ]
Yang, Yang [1 ,2 ]
Chen, Yao [1 ,2 ]
Wei, Meng-Ning [1 ,2 ]
Huang, Jia-Rong [1 ,2 ]
Wang, Kun [1 ,2 ]
Wei, Xing [1 ,2 ]
Shi, Zhi [1 ,2 ]
机构
[1] Jinan Univ, Dept Cell Biol, Natl Engn Res Ctr Genet Med, Guangdong Prov Key Lab Bioengn Med, Room 708,2nd Engineer & Sci Bldg, Guangzhou 510632, Guangdong, Peoples R China
[2] Jinan Univ, Inst Biomed, Coll Life Sci & Technol, Natl Engn Res Ctr Genet Med,Guangdong Prov Key La, Room 708,2nd Engineer & Sci Bldg, Guangzhou 510632, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Hosp 3, Ctr Clin Immunol, Guangzhou 510630, Guangdong, Peoples R China
[4] Guangdong Acad Med Sci, Guangdong Gen Hosp, Dept Gastrointertinal Surg & Gen Surg, Guangzhou 510080, Guangdong, Peoples R China
[5] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Urol, Guangzhou 510630, Guangdong, Peoples R China
来源
AMERICAN JOURNAL OF CANCER RESEARCH | 2016年 / 6卷 / 11期
关键词
Hepatocellular carcinoma; volasertib; ROS; apoptosis; POLO-LIKE KINASE; PHASE-I; INHIBITOR VOLASERTIB; BI; 6727; PRECLINICAL MODELS; JAPANESE PATIENTS; DOSE-ESCALATION; OPEN-LABEL; CANCER; TRIAL;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Hepatocellular carcinoma (HCC) is the sixth most frequent malignant tumor with poor prognosis, and its clinical therapeutic outcome is poor. Volasertib, a potent small molecular inhibitor of polo-like kinase 1 (PLK1), is currently tested for treatment of multiple cancers in the clinical trials. However, the antitumor effect of volasertib on HCC is still unknown. In this study, our data show that volasertib is able to induce cell growth inhibition, cell cycle arrest at G2/M phase and apoptosis with the spindle abnormalities in human HCC cells. Furthermore, volasertib also increases the intracellular reactive oxidative species (ROS) levels, and pretreated with ROS scavenger N-acety-L- cysteine partly reverses volasertib-induced apoptosis. Moreover, volasertib markedly inhibits the subcutaneous xenograft growth of HCC in nude mice. Overall, our study provides new therapeutic potential of volasertib on hepatocellular carcinoma.
引用
收藏
页码:2476 / 2488
页数:13
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