A randomized controlled trial of intranasal ketamine in migraine with prolonged aura

被引：111

作者：

Afridi, Shazia K. ^{[1
]}

Giffin, Nicola J. ^{[1
]}

Kaube, Holger ^{[1
]}

Goadsby, Peter J. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Neurol, Headache Grp, San Francisco, CA 94143 USA

来源：

NEUROLOGY | 2013年 / 80卷 / 07期

关键词：

CORTICAL SPREADING DEPRESSION; GLUTAMATE-RECEPTOR BLOCKADE; LONGITUDINAL DATA-ANALYSIS; SUSCEPTIBILITY; SUMATRIPTAN; ANTAGONISTS;

D O I：

10.1212/WNL.0b013e3182824e66

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: The aim of our study was to test the hypothesis that ketamine would affect aura in a randomized controlled double-blind trial, and thus to provide direct evidence for the role of glutamatergic transmission in human aura. Methods: We performed a double-blinded, randomized parallel-group controlled study investigating the effect of 25 mg intranasal ketamine on migraine with prolonged aura in 30 migraineurs using 2 mg intranasal midazolam as an active control. Each subject recorded data from 3 episodes of migraine. Results: Eighteen subjects completed the study. Ketamine reduced the severity (p = 0.032) but not duration of aura in this group, whereas midazolam had no effect. Conclusions: These data provide translational evidence for the potential importance of glutamatergic mechanisms in migraine aura and offer a pharmacologic parallel between animal experimental work on cortical spreading depression and the clinical problem.

引用

页码：642 / 647

页数：6

共 38 条

[21]

LIANG KY, 1986, BIOMETRIKA, V73, P13, DOI 10.1093/biomet/73.1.13

[22] EVIDENCE FOR A ROLE OF THE N-METHYL-D-ASPARTATE (NMDA) RECEPTOR IN CORTICAL SPREADING DEPRESSION IN THE RAT [J].

MARRANNES, R ;

WILLEMS, R ;

DEPRINS, E ;

WAUQUIER, A .

BRAIN RESEARCH, 1988, 457 (02) :226-240

[23] A delayed class of BOLD waveforms associated with spreading depression in the feline cerebral cortex can be detected and characterised using independent component analysis (ICA) [J].

Netsiri, C ;

Bradley, DP ;

Takeda, T ;

Smith, MI ;

Papadakis, N ;

Hall, LD ;

Parsons, AA ;

James, MF ;

Huang, CLH .

MAGNETIC RESONANCE IMAGING, 2003, 21 (09) :1097-1110

[24] No effect of eletriptan administration during the aura phase of migraine [J].

Olesen, J ;

Diener, HC ;

Schoenen, J ;

Hettiarachchi, J .

EUROPEAN JOURNAL OF NEUROLOGY, 2004, 11 (10) :671-677

[25] TOLERANCE TO KETAMINE-INDUCED BLOCKADE OF CORTICAL SPREADING DEPRESSION TRANSFERS TO MK-801 BUT NOT TO AP5 IN RATS [J].

RASHIDYPOUR, A ;

MOTAGHEDLARIJANI, Z ;

BURES, J .

BRAIN RESEARCH, 1995, 693 (1-2) :64-69

[26] A POPULATION-BASED ANALYSIS OF THE DIAGNOSTIC-CRITERIA OF THE INTERNATIONAL-HEADACHE-SOCIETY [J].

RASMUSSEN, BK ;

JENSEN, R ;

OLESEN, J .

CEPHALALGIA, 1991, 11 (03) :129-134

[27] Successful treatment of persistent migraine aura with divalproex sodium [J].

Rothrock, JF .

NEUROLOGY, 1997, 48 (01) :261-262

[28] Aborting a prolonged migrainous aura with intravenous prochlorperazine and magnesium sulfate [J].

Rozen, TD .

HEADACHE, 2003, 43 (08) :901-903

[29] Treatment of a prolonged migrainous aura with intravenous furosemide [J].

Rozen, TD .

NEUROLOGY, 2000, 55 (05) :732-733

[30] A nosographic analysis of the migraine aura in a general population [J].

Russell, MB ;

Olesen, J .

BRAIN, 1996, 119 :355-361

← 1 2 3 4 →