A randomized controlled trial of intranasal ketamine in migraine with prolonged aura

被引：111

作者：

Afridi, Shazia K. ^{[1
]}

Giffin, Nicola J. ^{[1
]}

Kaube, Holger ^{[1
]}

Goadsby, Peter J. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Neurol, Headache Grp, San Francisco, CA 94143 USA

来源：

NEUROLOGY | 2013年 / 80卷 / 07期

关键词：

CORTICAL SPREADING DEPRESSION; GLUTAMATE-RECEPTOR BLOCKADE; LONGITUDINAL DATA-ANALYSIS; SUSCEPTIBILITY; SUMATRIPTAN; ANTAGONISTS;

D O I：

10.1212/WNL.0b013e3182824e66

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: The aim of our study was to test the hypothesis that ketamine would affect aura in a randomized controlled double-blind trial, and thus to provide direct evidence for the role of glutamatergic transmission in human aura. Methods: We performed a double-blinded, randomized parallel-group controlled study investigating the effect of 25 mg intranasal ketamine on migraine with prolonged aura in 30 migraineurs using 2 mg intranasal midazolam as an active control. Each subject recorded data from 3 episodes of migraine. Results: Eighteen subjects completed the study. Ketamine reduced the severity (p = 0.032) but not duration of aura in this group, whereas midazolam had no effect. Conclusions: These data provide translational evidence for the potential importance of glutamatergic mechanisms in migraine aura and offer a pharmacologic parallel between animal experimental work on cortical spreading depression and the clinical problem.

引用

页码：642 / 647

页数：6

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