Gallic acid: Molecular rival of cancer

被引：302
作者：
Verma, Sharad [1 ]
Singh, Amit [2 ]
Mishra, Abha [1 ]
机构：
[1] Banaras Hindu Univ, Sch Biochem Engn, Indian Inst Technol, Varanasi 221005, Uttar Pradesh, India
[2] Banaras Hindu Univ, Inst Med Sci, Dept Pharmacol, Varanasi 221005, Uttar Pradesh, India
来源：
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2013年 / 35卷 / 03期
关键词：
Gallic acid; Cancer; COX; NF-KAPPA-B; PERMEABILITY TRANSITION PORE; UDP-GLUCOSE DEHYDROGENASE; NECROSIS-FACTOR-ALPHA; HEMATOPOIETIC STEM/PROGENITOR CELLS; HOMING-RELATED RESPONSES; NITRIC-OXIDE SYNTHASE; RIBONUCLEOTIDE REDUCTASE; IN-VIVO; BONE-MARROW;
D O I：
10.1016/j.etap.2013.02.011
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Gallic acid, a predominant polyphenol, has been shown to inhibit carcinogenesis in animal models and in vitro cancerous cell lines. The inhibitory effect of gallic acid on cancer cell growth is mediated via the modulation of genes which encodes for cell cycle, metastasis, angiogenesis and apoptosis. Gallic acid inhibits activation of NF-kappa B and Akt signaling pathways along with the activity of COX, ribonucleotide reductase and GSH. Moreover, gallic acid activates ATM kinase signaling pathways to prevent the processes of carcinogenesis. The data so far available, both from in vivo and in vitro studies, indicate that this dietary polyphenol could be promising agent in the field of cancer chemoprevention. (c) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：473 / 485
页数：13
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