Green tea extract alleviates arsenic-induced biochemical toxicity and lipid peroxidation in rats

被引：36

作者：

Messarah, Mahfoud ^{[1
]}

Saoudi, Mongi ^{[2
]}

Boumendjel, Amel ^{[3
]}

Kadeche, Lilia ^{[1
]}

Boulakoud, Mohamed Salah ^{[1
]}

El Feki, Abdelfattah ^{[2
]}

机构：

[1] Badji Mokhtar Univ, Fac Sci, Anim Ecophysiol Lab, Annaba, Algeria

[2] Fac Sci, Anim Ecophysiol Lab, Sfax, Tunisia

[3] Badji Mokhtar Univ, Fac Sci, Appl Biochem & Microbiol Lab, Annaba, Algeria

来源：

TOXICOLOGY AND INDUSTRIAL HEALTH | 2013年 / 29卷 / 04期

关键词：

Arsenic; biochemical parameters; green tea; protective effect; lipid peroxidation; rat; INDUCED OXIDATIVE STRESS; GLUCOSE-HOMEOSTASIS; NERVOUS-SYSTEM; DRINKING-WATER; FREE-RADICALS; CELLS; LIVER; CANCER; DAMAGE; EXPOSURE;

D O I：

10.1177/0748233711433934

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The present work was undertaken to evaluate the protective effect of an aqueous extract of green tea (GT, Camellia sinensis) leaves against arsenic (NaAsO2)-induced biochemical toxicity and lipid peroxidation production in experimental rats. The treatment with arsenic exhibited a significant increase in some serum hepatic and renal biochemical parameters (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total protein, albumin, bilirubin, cholesterol, urea and creatinine). But the co-administration of GT has increased the level of plasmatic concentration of biochemical parameters. Exposure of rats to arsenic caused also a significant increase in liver, kidney and testicular thiobarbituric acid reactive substances compared to control. However, the co-administration of GT was effective in reducing its level. To conclude, our data suggest that arsenic exposure enhanced an oxidative stress by disturbing the tissue antioxidant defense system, but the GT co-administration alleviates the toxicity induced by arsenic exposure.

引用

页码：349 / 359

页数：11

共 76 条

[1] Oxidative stress by inorganic arsenic: modulation by thyroid hormones in rat [J].