Association of gamma-glutamyltransferase with severity of disease at diagnosis and prognosis of ovarian cancer

被引:96
作者
Grimm, C. [1 ]
Hofstetter, G. [2 ]
Aust, S. [1 ]
Mutz-Dehbalaie, I. [3 ]
Bruch, M. [3 ]
Heinze, G. [4 ]
Rahhal-Schupp, J. [1 ]
Reinthaller, A. [1 ,5 ]
Concin, N. [3 ]
Polterauer, S. [1 ]
机构
[1] Med Univ Vienna, Gynecol Canc Unit, Ctr Comprehens Canc, Dept Gen Gynecol & Gynecol Oncol, A-1090 Vienna, Austria
[2] Mem Sloan Kettering Canc Ctr, Dept Surg, Gynecol Serv, New York, NY 10065 USA
[3] Med Univ Innsbruck, Dept Obstet & Gynecol, A-6010 Tyrol, Austria
[4] Med Univ Vienna, Ctr Med Stat Informat & Intelligent Syst, A-1090 Vienna, Austria
[5] Karl Landsteiner Inst Gen Gynecol & Expt Gynecol, A-2824 Seebenstein, Austria
关键词
ovarian cancer; gamma-glutamyltransferase; gamma-glutamyltranspeptidase (GGT); prognosis; DRUG-RESISTANCE; CERVICAL-CANCER; MELANOMA-CELLS; GROWTH; RISK; GLUTATHIONE; MUTAGENESIS; MODULATION; EXPRESSION; LIVER;
D O I
10.1038/bjc.2013.323
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Gamma-glutamyltransferase (GGT) - a membrane-bound enzyme crucially involved in the cell's detoxification pathway and apoptotic balance - is involved in tumour development, progression and chemotherapy resistance. Elevated GGT serum levels are associated with increased cancer risk in women and worse prognosis in gynaecologic cancers. The present study investigated the prognostic role of GGT in ovarian cancer patients. Methods: In this multicenter study, pre-therapeutic GGT levels were ascertained in 634 consecutive patients with epithelial ovarian cancer (EOC, n = 567) and borderline tumour of the ovary (BTO, n = 67). Gamma-glutamyltransferase serum levels were associated with clinicopathological parameters and uni- and multivariate survival analyses were performed. Immunohistochemistry of GGT was performed in ovarian cancer tissue and correlated with GGT serum levels. Results: Pre-therapeutic GGT serum levels were higher in patients with EOC (28.56 (38.24) Ul(-1)) than in patients with BTO (20.01 (12.78) Ul(-1), P = 0.01). High GGT serum levels were associated with advanced FIGO stage (P<0.001) and with worse overall survival in univariate (P<0.001) and multivariable analysis (P = 0.02, HR 1.2 (1.1-1.5)). We further investigated the association between systemic GGT serum levels and local GGT expression in EOC tumour tissue and observed an association between these two parameters (P = 0.03). Conclusion: High pre-therapeutic GGT serum levels are associated with advanced tumour stage and serve as an independent prognostic marker for worse overall survival in patients with EOC. Gamma-glutamyltransferase expression in ovarian cancer tissue is reflected in GGT serum levels.
引用
收藏
页码:610 / 614
页数:5
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