Induction of apoptosis and inhibition of cellular proliferation as a dual approach to treatment of ovarian cancer

被引：0

作者：

Edwards, J ^{[1
]}

Bartlett, JMS ^{[1
]}

机构：

[1] Univ Glasgow, Royal Infirm, Dept Surg, Glasgow G31 2ER, Lanark, Scotland

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 1999年 / 15卷 / 03期

关键词：

ovarian cancer; apoptosis; EGF receptor inhibitor;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Inhibition of mitosis or induction of apoptosis are pathways at which anti tumour therapies could be aimed. This study evaluates the actions of CGP52411 (cell growth inhibitor) and transforming growth factor beta 1 (TGF beta 1) (inducer of apoptosis) alone and in combination on two ovarian carcinoma cell lines (PEO1 and OVCAR3). In both cell lines TGF beta 1 treatment increased the level of apoptotic cells and CGP52411 treatment reduced EGF stimulated cell growth. Combined treatment further reduced cell numbers in PEO1 cultures, demonstrating that dual therapy aimed at both aspects of cell regulation has a greater anti tumour action.

引用

页码：583 / 588

页数：6

共 20 条

[1] TRANSFORMING GROWTH-FACTOR-BETA MESSENGER-RNA EXPRESSION AND GROWTH-CONTROL OF HUMAN OVARIAN-CARCINOMA CELLS [J].

BARTLETT, JMS ;

RABIASZ, GJ ;

SCOTT, WN ;

LANGDON, SP ;

SMYTH, JF ;

MILLER, WR .

BRITISH JOURNAL OF CANCER, 1992, 65 (05) :655-660

[2] REGULATION OF GROWTH OF NORMAL OVARIAN EPITHELIAL-CELLS AND OVARIAN-CANCER CELL-LINES BY TRANSFORMING GROWTH-FACTOR-BETA [J].

BERCHUCK, A ;

RODRIGUEZ, G ;

OLT, G ;

WHITAKER, R ;

BOENTE, MP ;

ARRICK, BA ;

CLARKEPEARSON, DL ;

BAST, RC .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1992, 166 (02) :676-684

[3]

CHIARA S, 1992, AM J CLIN ONCOL-CANC, V17, P293

[4] Endogenous glucocorticoids induced by a chemical stressor (ethanol) cause apoptosis in the spleen in B6C3F1 female mice [J].

Collier, SD ;

Wu, WJ ;

Pruett, SB .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1998, 148 (01) :176-182

[5] RESPONSE, 2ND LOOK STATUS AND SURVIVAL IN STAGE-III-IV EPITHELIAL OVARIAN-CANCER TREATED WITH CIS-DICHLORODIAMMINE PLATINUM-II (CIS-PLATINUM), ADRIAMYCIN (ADR), AND CYTOXAN (CTX) [J].

EHRLICH, CE ;

EINHORN, LH ;

STEHMAN, FB ;

ROTH, LM ;

BLESSING, J .

GYNECOLOGIC ONCOLOGY, 1980, 10 (03) :367-368

[6]

HARVRILIESKY LJ, 1995, CANCER RES, V55, P944

[7] Expression of epidermal growth factor and androgen receptors in ovarian cancer [J].

Ilekis, JV ;

Conner, JP ;

Prins, CS ;

Ferrer, K ;

Niederberger, C ;

Scoccia, B .

GYNECOLOGIC ONCOLOGY, 1997, 66 (02) :250-254

[8] Protein tyrosine kinase inhibitors prevent didemnin B-induced apoptosis in HL-60 cells [J].

Johnson, KL ;

Vaillant, F ;

Lawen, A .

FEBS LETTERS, 1996, 383 (1-2) :1-5

[9] TRANSFORMING GROWTH FACTOR-BETA-1 (TGF-BETA-1) INHIBITS GROWTH OF A HUMAN OVARIAN-CARCINOMA CELL-LINE (OVCCR1) AND IS EXPRESSED IN HUMAN OVARIAN-TUMORS [J].

JOZAN, S ;

GUERRIN, M ;

MAZARS, P ;

DUTAUR, M ;

MONSARRAT, B ;

CHEUTIN, F ;

BUGAT, R ;

MARTEL, P ;

VALETTE, A .

INTERNATIONAL JOURNAL OF CANCER, 1992, 52 (05) :766-770

[10] Molecular approaches to diagnosis and management of ovarian cancer [J].

Katso, RMT ;

Manek, S ;

OByrne, K ;

Playford, MP ;

LeMeuth, V ;

Ganesan, TS .

CANCER AND METASTASIS REVIEWS, 1997, 16 (1-2) :81-107

← 1 2 →