Canonical and non-canonical adenosinergic pathways

被引：64

作者：

Ferretti, E. ^{[1
]}

Horenstein, A. L. ^{[2
,3
]}

Canzonetta, C. ^{[4
]}

Costa, F. ^{[5
,6
]}

Morandi, F. ^{[7
,8
]}

机构：

[1] Ist Giannina Gaslini, Expt Therapies Oncol, Genoa, Italy

[2] Univ Torino, Dept Med Sci, Lab Immunogenet, Turin, Italy

[3] Univ Torino, CeRMS, Turin, Italy

[4] Pediat Hosp Bambino Gesu, Immunol Area, Rome, Italy

[5] Univ Parma, Dept Med & Surg, Parma, Italy

[6] Univ Parma, Azienda Osped, Hematol Unit, Parma, Italy

[7] Ist Giannina Gaslini, Stem Cell Lab, Via Gaslini 1, I-16148 Genoa, Italy

[8] Ist Giannina Gaslini, Cell Therapy Ctr, Via Gaslini 1, I-16148 Genoa, Italy

来源：

IMMUNOLOGY LETTERS | 2019年 / 205卷

关键词：

Adenosine; Immunosuppression; Ectoenzymes; REGULATORY T-CELLS; MESENCHYMAL STEM-CELLS; PLASMA-CONCENTRATION; POOR-PROGNOSIS; CD73; CD39; EXPRESSION; CANCER; ATP; SUPPRESSION;

D O I：

10.1016/j.imlet.2018.03.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Adenosine (ADO) is an immunosuppressive molecule with multiple functions in different human organs. ADO is released through the concerted action of surface molecules endowed with enzymatic functions, that belong to two different adenosinergic pathways. The canonical pathway is started by CD39, that converts ATP to AMP. On the other hand, the non-canonical pathway metabolizes NAD(+) to ADPR, through the action of CD38. The latter byproduct is then converted to AMP by CD203a/PC-1. Both pathways converge to CD73, that fully degrades AMP to the final product ADO. In this Review we take into account the most relevant finding regarding the expression of ectoenzymes belonging to both adenosinergic pathways in different cell types, including regulatory cell subsets and neoplastic cells. Moreover, we summarize the role of these molecules in different physiological and pathological settings. Finally, we discuss potential therapeutic application of specific inhibitors of ectoenzymes and/or ADO receptors.

引用

页码：25 / 30

页数：6

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